The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the structure–activity relationship revealed that the 3,5-dimethyl-1H-pyrazol-1-yl moiety linked to the carbon C-9 of the pyrimidine plays a decisive role in the manifestation of activity. The influence of 3,5-dimethyl-1H-pyrazol-1-yl group on the Dimroth rearrangement and azide-tetrazole equilibrium has also been examined.

中文翻译：

---

环戊[4'，5']吡啶[3'，2'：4,5]呋喃[3,2-d]嘧啶衍生的新型多杂环体系的合成及抗菌性能评估

已经进行了新的环戊基[4'，5']吡啶基[3'，2'：4,5]呋喃[3,2 - d ]嘧啶-7-胺的合成以研究其抗菌活性。生物学测试表明，某些合成的化合物具有明显的抗菌性能。对结构-活性关系的研究表明，连接到嘧啶碳C-9的3,5-二甲基-1 H-吡唑-1-基部分在活性的表现中起决定性作用。还研究了3,5-二甲基-1 H-吡唑-1-基对Dimroth重排和叠氮化物-四唑平衡的影响。