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Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine

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Chemistry of Heterocyclic Compounds Aims and scope

The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The biological tests evidenced that some of the synthesized compounds exhibit pronounced antimicrobial properties. A study of the structure–activity relationship revealed that the 3,5-dimethyl-1H-pyrazol-1-yl moiety linked to the carbon C-9 of the pyrimidine plays a decisive role in the manifestation of activity. The influence of 3,5-dimethyl-1H-pyrazol-1-yl group on the Dimroth rearrangement and azide-tetrazole equilibrium has also been examined.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A. L. Mnjoyan, 26 Azatutyan Ave, 0014, Yerevan, Armenia

    Samvel N. Sirakanyan, Hrachya M. Stepanyan, Elmira K. Hakobyan & Anush A. Hovakimyan

  2. Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum-Università di Bologna, Via F. Selmi 2, 40126, Bologna, Italy

    Domenico Spinelli

  3. Aristotle University of Thessaloniki, School of Pharmacy, 54124, Thessaloniki, Greece

    Athina Geronikaki

  4. InterBioScreen Ltd., P. O. Box 218, Moscow, 119019, Russia

    Victor G. Kartsev

Authors
  1. Samvel N. Sirakanyan
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  2. Domenico Spinelli
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  3. Athina Geronikaki
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  4. Victor G. Kartsev
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  5. Hrachya M. Stepanyan
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  6. Elmira K. Hakobyan
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  7. Anush A. Hovakimyan
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Corresponding authors

Correspondence to Samvel N. Sirakanyan or Domenico Spinelli.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(1), 75–80

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Sirakanyan, S.N., Spinelli, D., Geronikaki, A. et al. Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine. Chem Heterocycl Comp 57, 75–80 (2021). https://doi.org/10.1007/s10593-021-02870-1

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  • DOI: https://doi.org/10.1007/s10593-021-02870-1

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