Skin acts as protective barrier against a number of factors such as dust, opportunistic microbial and viral infections, regulates body temperature and waste discharge. Fibroblast cell population plays an important role in development of skin architecture. A scaffold having capability to support and enhance fibroblast growth is a viable option for wound dressing material which can shorten the time for wound to heal. In this work, Silk Fibroin (SF) and Xanthan (Xa) were blended in three ratios 80 SF: 20 Xa (SFX82), 60 SF: 40 Xa (SFX64), and 50 SF: 50 Xa (SFX55) to create SF/Xa scaffold. Miscibility and other physicochemical properties of SF/Xa scaffold are functions of blending ratios and blend with the ratio 80 SF: 20 Xa has the highest miscibility. Thermal properties of SF/Xa blends are a function of miscibility with SFX82 having superior thermal properties of all fabricated scaffolds. The porosity of SF/Xa scaffolds is in the range of 67% to 50%, with pore size of 58.1 µm–45.5 µm, water uptake capacity of 92%–86%, and surface roughness of 49.95 nm–385 nm. SFX82 shows highest growth rate of L929 fibroblast cells indicating its superiority over other scaffolds for providing biological cues for the growth and proliferation of fibroblastic cells in natural environment. SFX82 scaffold is found to be most suitable for fibroblastic cells thereby enhancing the tissue regeneration at wound site.

皮肤可作为抵抗多种因素的保护屏障，例如灰尘，机会性微生物和病毒感染，调节体温和废物排放。成纤维细胞群在皮肤结构发展中起重要作用。具有支持和促进成纤维细胞生长的能力的支架是伤口敷料材料的可行选择，其可以缩短伤口愈合的时间。在这项工作中，将丝素蛋白（SF）和黄原胶（Xa）按以下三种比例混合：80 SF：20 Xa（SFX82），60 SF：40 Xa（SFX64）和50 SF：50 Xa（SFX55）。 Xa脚手架。SF / Xa支架的可混溶性和其他理化性质是共混比的函数，并且以80 SF的比例共混：20 Xa具有最高的可混溶性。SF / Xa共混物的热性能是与SFX82混溶的函数，SFX82在所有预制支架中均具有出色的热性能。SF / Xa支架的孔隙率范围为67％至50％，孔径为58.1 µm–45.5 µm，吸水率为92％–86％，表面粗糙度为49.95 nm–385 nm。SFX82显示L929成纤维细胞的最高生长速率，表明它优于其他支架，可为自然环境中成纤维细胞的生长和增殖提供生物学线索。发现SFX82支架最适合成纤维细胞，从而增强伤口部位的组织再生。95 nm至385 nm。SFX82显示L929成纤维细胞的最高生长速率，表明它优于其他支架，可为自然环境中成纤维细胞的生长和增殖提供生物学线索。发现SFX82支架最适合成纤维细胞，从而增强伤口部位的组织再生。95 nm至385 nm。SFX82显示L929成纤维细胞的最高生长速率，表明它优于其他支架，可为自然环境中成纤维细胞的生长和增殖提供生物学线索。发现SFX82支架最适合成纤维细胞，从而增强伤口部位的组织再生。