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Study of the Anticancer Activity of a New Nanosize Bismuth(V)-Based Coordination Complex Against Human Bone Tumor Cells
Journal of Chemical Crystallography ( IF 0.4 ) Pub Date : 2021-01-27 , DOI: 10.1007/s10870-021-00879-0
Lei Pan , Yang Liu , Ming Bian , Dong Zhen , Zhi-Fang Zhang , Xien Feng

Herein we report a new bismuth(V)-based coordination complex Bi(phenyl)3(2,5-dfa)2 (1) that has been successfully prepared by using C donor phenyl ring and O donor 2,5-difluorobenzoic acid (2,5-H2dfa) ligands. The coordination complex has been comprehensively characterized by single crystal X-ray diffraction, Powder X-ray diffraction and thermogravimetric analysis. Finally, an evaluation of cytotoxicity against human OS-732 bone tumor cell lines for the synthesized nanoparticles was performed.

Graphic Abstract

A new bismuth(V)-based coordination complex Bi(phenyl)3(2,5-dfa)2 (1) has been successfully prepared and evaluation of cytotoxicity against human OS-732 bone tumor cell lines for its related nanoparticles was performed.



中文翻译:

基于纳米铋(V)的新型配位复合物对人骨肿瘤细胞抗癌活性的研究

在此,我们报告了一种新的基于铋(V)的配位化合物Bi(苯基)3(2,5-dfa)21),该化合物已通过使用C供体苯环和O供体2,5-二氟苯甲酸成功制备( 2,5-H 2 dfa)配体。通过单晶X射线衍射,粉末X射线衍射和热重分析对配位化合物进行了全面表征。最后,对合成的纳米颗粒对人OS-732骨肿瘤细胞系的细胞毒性进行了评估。

图形摘要

一种新的基于铋(V)的配位配合物Bi(苯基)3(2,5-dfa)2(1)已成功制备,并对其相关纳米粒子对人OS-732骨肿瘤细胞系进行了细胞毒性评估。

更新日期:2021-01-28
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