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Study of the Anticancer Activity of a New Nanosize Bismuth(V)-Based Coordination Complex Against Human Bone Tumor Cells

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Abstract

Herein we report a new bismuth(V)-based coordination complex Bi(phenyl)3(2,5-dfa)2 (1) that has been successfully prepared by using C donor phenyl ring and O donor 2,5-difluorobenzoic acid (2,5-H2dfa) ligands. The coordination complex has been comprehensively characterized by single crystal X-ray diffraction, Powder X-ray diffraction and thermogravimetric analysis. Finally, an evaluation of cytotoxicity against human OS-732 bone tumor cell lines for the synthesized nanoparticles was performed.

Graphic Abstract

A new bismuth(V)-based coordination complex Bi(phenyl)3(2,5-dfa)2 (1) has been successfully prepared and evaluation of cytotoxicity against human OS-732 bone tumor cell lines for its related nanoparticles was performed.

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Acknowledgement

This work was supported by the Natural Science Foundation of Inner Mongolia Autonomous (No. 2020BS08013) and the Project of Inner Mongolia University for the Nationalities (NMDYB1723, NMDYB17168).

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Author notes

  1. Lei Pan and Yang Liu contributed equally to this work.

Authors and Affiliations

  1. Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, 028000, Inner Mongolia, China

    Lei Pan & Yang Liu

  2. Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, 028000, Inner Mongolia Autonomous Region, China

    Ming Bian & Dong Zhen

  3. Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, 028000, Inner Mongolia Autonomous Region, China

    Ming Bian & Dong Zhen

  4. Department of Nursing, Tongliao City Hospital, Tongliao, 028000, Inner Mongolia Autonomous Region, China

    Zhi-Fang Zhang

  5. Department of Pharmacy, Second People Hospital, Chongqing, 400013, China

    Xien Feng

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  1. Lei Pan
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  2. Yang Liu
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  3. Ming Bian
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  4. Dong Zhen
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  5. Zhi-Fang Zhang
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  6. Xien Feng
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Correspondence to Ming Bian or Dong Zhen.

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Pan, L., Liu, Y., Bian, M. et al. Study of the Anticancer Activity of a New Nanosize Bismuth(V)-Based Coordination Complex Against Human Bone Tumor Cells. J Chem Crystallogr 51, 553–561 (2021). https://doi.org/10.1007/s10870-021-00879-0

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  • DOI: https://doi.org/10.1007/s10870-021-00879-0

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