A Ru(II)–BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(II) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.

中文翻译：

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溶酶体靶向和近红外吸收Ru（II）-BODIPY偶联物的光动力学治疗的合理设计

合理设计了Ru（II）-BODIPY偶联物，并在NIR区域表现出强烈的吸收作用，以在体外和体内增强溶酶体靶向的PDT 。成功地将Ru（II）和BODIPY的优势灌输到缀合物中，以产生针对恶性黑色素瘤A375细胞（PI = 3448）和A375小鼠异种移植物的高效PDT功效。