Issue 14, 2021
From the journal:

Chemical Communications

Rational design of a lysosome-targeting and near-infrared absorbing Ru(ii)–BODIPY conjugate for photodynamic therapy†

Liping Qiao,a   Jiangping Liu,*a   Yunhong Han,a   Fangmian Wei,a   Xinxing Liao,a   Cheng Zhang,a   Lina Xie,a   Liangnian Jia  and  Hui Chao ORCID logo *ab  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, cesliujiangping@foxmail.com

b MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China

Abstract

A Ru(II)–BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(II) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.

Graphical abstract: Rational design of a lysosome-targeting and near-infrared absorbing Ru(ii)–BODIPY conjugate for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D0CC06926D
Article type
Communication
Submitted
18 Oct 2020
Accepted
11 Jan 2021
First published
11 Jan 2021

Chem. Commun., 2021,57, 1790-1793

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Rational design of a lysosome-targeting and near-infrared absorbing Ru(II)–BODIPY conjugate for photodynamic therapy

L. Qiao, J. Liu, Y. Han, F. Wei, X. Liao, C. Zhang, L. Xie, L. Ji and H. Chao, Chem. Commun., 2021, 57, 1790 DOI: 10.1039/D0CC06926D

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