The red blood cell (RBC) is unique in terms of its structure and function when compared to other cells in the blood and body. Its anucleated characteristic and biconcave shape (indicative of high surface area to volume ratio) render it deformable. This deformability is useful during circulation when the red blood cell has to traverse capillaries smaller than its size. The cytoskeleton of the red blood cell, a two dimensional sheet like structure with dynamic linkages, plays a major role in its deformability. The interdependent relationship between the cytoskeleton and RBC deformability under various conditions such as metabolism, hematologic and systemic disorders and senescence is reviewed.

中文翻译：

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红细胞的细胞骨架在其变形能力中的作用

与血液和身体中的其他细胞相比，红细胞 (RBC) 在其结构和功能方面是独一无二的。其无核特性和双凹面形状（表明表面积与体积比高）使其可变形。当红细胞必须穿过小于其尺寸的毛细血管时，这种变形能力在循环过程中很有用。红细胞的细胞骨架是一种具有动态连接的二维片状结构，在其可变形性中起主要作用。综述了在代谢、血液学和全身性疾病以及衰老等各种条件下细胞骨架和红细胞变形能力之间的相互依赖关系。