Cancer therapy triggered by various cell death pathways has attracted widespread attention to improve therapeutic efficiency. Herein, an immunomodulatory polysaccharide (galactoxyloglucan) coated iron oxide nanoconjugate, with a diameter of about 10 nm, is made-up to intracellularly trigger the Fenton reaction and achieve cell death. The nanoconjugate based on iron oxide nanoparticles (PIONPs) exhibits excellent biocompatibility, stability and can be used as an imaging agent. Moreover, importantly it can effectively generate reactive oxygen species (ROS) for tumor eradication with no systemic toxicity. In vitro and In vivo experiments reveal that the PIONPs can intratumorally accumulate and serves as an excellent MRI contrast agent.

由各种细胞死亡途径引发的癌症治疗已引起广泛关注，以提高治疗效率。在此，构成直径约10nm的免疫调节多糖（半乳糖氧基葡聚糖）包被的氧化铁纳米缀合物以在细胞内触发Fenton反应并实现细胞死亡。基于氧化铁纳米粒子（PIONPs）的纳米共轭物表现出优异的生物相容性，稳定性，可用作成像剂。而且，重要的是，它可以有效地产生活性氧（ROS），用于根除肿瘤而没有全身毒性。体外和体内实验表明，PIONPs可以在肿瘤内蓄积，并作为出色的MRI造影剂。