The tissue reaction of pig skin to implantation of decellularized and recellularized dermal matrices on a formed wound defect was evaluated by histological methods on days 2, 5, 8, 16, and 20 after surgery. Differences in tissue response to different matrices were identified. In experimental wounds coated with decellularized dermal matrices, we observed the formation of a scar tissue, which required autodermoplasty on day 12 of the experiment. In wounds coated with recellularized dermal matrices, all layers of the skin completely recovered by day 20 after surgery with the formation of full dermal and epidermal layers. Our findings suggest that reparative morphological changes in the wound depend on the presence of fibroblasts in the implanted dermal matrix.

中文翻译：

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去细胞化和再细胞化猪皮肤支架植入结果的比较形态学特征

在手术后第 2、5、8、16 和 20 天，通过组织学方法评估猪皮肤对脱细胞和再细胞真皮基质植入形成的伤口缺损的组织反应。确定了组织对不同基质的反应的差异。在涂有脱细胞真皮基质的实验伤口中，我们观察到疤痕组织的形成，这需要在实验的第 12 天进行自体皮肤成形术。在涂有再细胞化真皮基质的伤口中，所有皮肤层在手术后第 20 天完全恢复，形成完整的真皮层和表皮层。我们的研究结果表明，伤口的修复形态变化取决于植入的真皮基质中成纤维细胞的存在。