Several types of cells show left–right asymmetric behavior, unidirectional rotation, or spiral movements. For example, neutrophil-like differentiated HL60 (dHL60) cells show leftward bias in response to chemoattractant. Neurons extend neurites, creating a clockwise spiral. Platelet cells shows unidirectional spiral arrangements of actin fibers. In the microfabricated culture environment, groups of C2C12 cells (mouse myoblast cell line) were autonomously aligned in a counter-clockwise spiral pattern, and isolated C2C12 cells showed unidirectional spiral pattern of the actin skeleton. This biased directionality suggested that these cells have inherent cell chirality. In addition to these cells, we recently found that melanophores of zebrafish also have an intrinsic cellular chirality that was shown by their counter-clockwise self-rotation. Although this cell chirality is obvious, the function of the cell chirality is still unclear. In this review, we compare the cell chirality of melanophores of zebrafish with other cell chirality and consider the function of cell chirality in morphogenesis.

中文翻译：

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斑马鱼黑素提示细胞手性在组织形成中的新功能。

几种类型的单元格显示左右不对称行为，单向旋转或螺旋运动。例如，嗜中性粒细胞样分化的HL60（dHL60）细胞显示出对趋化因子的偏向。神经元延伸神经突，形成顺时针螺旋。血小板细胞显示肌动蛋白纤维的单向螺旋排列。在微细的培养环境中，成组的C2C12细胞（小鼠成肌细胞细胞系）以逆时针螺旋状自动排列，而分离的C2C12细胞则显示出肌动蛋白骨架的单向螺旋状。这种偏向的方向性提示这些细胞具有固有的细胞手性。除了这些细胞外，我们最近还发现斑马鱼的黑色素细胞也具有内在的细胞手性，这可以通过它们逆时针的自转来显示。尽管这种细胞手性是明显的，但是细胞手性的功能仍不清楚。在这篇综述中，我们比较了斑马鱼黑素细胞的细胞手性与其他细胞手性，并考虑了细胞手性在形态发生中的功能。