Polyacrylamide conjugates of glycans have long been widely used in many research areas of glycobiology, mainly for immobilizing glycans in solid-phase assays and as multivalent inhibitors. Pending biotin tag allows immobilizing Glyc-PAA quantitatively on any surface, and acts as a tracer for detection of carbohydrate-binding proteins. However, the scope of already realized capabilities of these probes is immeasurably richer than those listed above. This review is not so much about routine as about less common, but not less significant applications. Also, the data on the glycopolymers themselves, their molecular weight, size and polymer chain flexibility are presented, as well as the methods of synthesis, clusterisation and entropy factor in their interaction with proteins.

聚糖的聚丙烯酰胺缀合物长期以来一直广泛用于糖生物学的许多研究领域，主要用于在固相测定中固定聚糖和作为多价抑制剂。待处理的生物素标签允许将 Glyc-PAA 定量固定在任何表面上，并充当检测碳水化合物结合蛋白的示踪剂。但是，这些探针已经实现的功能范围比上面列出的要丰富得多。这篇评论与其说是关于常规，不如说是关于不太常见但并非不那么重要的应用程序。此外，还介绍了糖聚合物本身、它们的分子量、大小和聚合物链柔韧性的数据，以及它们与蛋白质相互作用的合成方法、聚类和熵因子。