This study aimed to present normative data of Quality of life (QoL) and to evaluate the relationship between sociodemographic factors, multidimensional QoL and depression. A questionnaire including the Short Form-12 (SF-12) for physical and mental health-related QOL (HRQOL), the McGill Quality of Life questionnaire (MQOL) for existential well-being and social support-related QOL, and the Patient Health Questionnaire-9 (PHQ-9) for depressive symptoms was designed and administered to 1200 Korean participants as part of a population-based survey. The MQOL of the entire and female population decreased notably with age (p < 0.001 for both), and women, 40-years-old individuals, and religious individuals had higher physical HRQOL (adjusted odds ratio [aOR] = 1.67, 2.14, and 1.31), and persons older than 40 years of age and with an income of >$3000 reported a better mental HRQOL (aOR = 1.42 and 1.38). Those who were educated at higher than college level or were religious reported a worse mental HRQOL (aOR = 0.70 and 0.69). Unlike QOL measured by the SF-12, MQOL was lower among women (aOR = 0.77) and participants who were divorced or separated (aOR = 0.23 for existential well-being and 0.40 for social support). Participants who were educated at higher than college level (aOR = 1.51) and those living in a city/country reported a better MQOL (aOR = 1.50 for existential well-being and 1.60 for social support). Among the QOL scores that were significantly related to depression, existential well-being-related QOL had the highest aOR (aOR = 38.15), followed by physical HRQOL score (aOR = 4.52). Further consideration is needed to raise awareness of the need for evaluating multidimensional QOL in the general population.

本研究旨在提供生活质量 (QoL) 的规范数据，并评估社会人口因素、多维 QoL 与抑郁之间的关系。问卷包括用于身心健康相关 QOL (HRQOL) 的 Short Form-12 (SF-12)、用于生存福祉和社会支持相关 QOL 的 McGill 生活质量问卷 (MQOL) 以及患者健康作为基于人群的调查的一部分，针对抑郁症状的问卷 9 (PHQ-9) 设计并用于 1200 名韩国参与者。整个人群和女性人群的 MQOL 随年龄增长显着下降（p < 0.001），女性、40 岁的人和宗教人士的身体 HRQOL 更高（调整后的优势比 [aOR] = 1.67、2.14 和 1.31），以及 40 岁以上的人收入超过 3000 美元的人报告了更好的心理 HRQOL（aOR = 1.42 和 1.38）。那些受过大学以上教育或有宗教信仰的人报告的心理 HRQOL 较差（aOR = 0.70 和 0.69）。与 SF-12 测量的 QOL 不同，MQOL 在女性 (aOR = 0.77) 和离婚或分居的参与者中较低（aOR = 0.23 代表生存幸福，0.40 代表社会支持）。受过大学以上教育的参与者 (aOR = 1.51) 和居住在城市/国家的参与者报告了更好的 MQOL（aOR = 1.50 代表生存幸福，1.60 代表社会支持）。在与抑郁症显着相关的 QOL 评分中，生存幸福相关 QOL 的 aOR 最高（aOR = 38.15），其次是身体 HRQOL 评分（aOR = 4.52）。需要进一步考虑以提高对在一般人群中评估多维 QOL 的必要性的认识。