Organ preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount of expanded criteria donor (ECD) organs are used clinically. Currently, the paradigm of organ preservation is shifting from simple reduction of cellular metabolic activity to maximal simulation of an ex vivo physiological microenvironment. An ideal organ preservation technique should not only preserve isolated organs but also offer the possibility of rehabilitation and evaluation of organ function prior to transplantation. Based on the fact that mesenchymal stromal cells (MSCs) possess strong regeneration properties, the combination of MSCs with machine perfusion (MP) is expected to be superior to conventional preservation methods. In recent years, several studies have attempted to use this strategy for SOT showing promising outcomes. With better organ function during ex vivo preservation and the potential of utilization of organs previously deemed untransplantable, this strategy is meaningful for patients with organ failure to help overcome organ shortage in the field of SOT.

中文翻译：

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间充质基质细胞和机器灌注的结合是实体器官移植中器官保存的新策略

器官保存是紧急增加实体器官移植 (SOT) 器官可用性的先决条件。越来越多的扩展标准供体 (ECD) 器官用于临床。目前，器官保存的范例正在从简单地减少细胞代谢活动转变为最大限度地模拟体外生理微环境。理想的器官保存技术不仅应保存离体器官，还应提供移植前器官功能的康复和评估的可能性。基于间充质基质细胞 (MSCs) 具有很强的再生特性，MSCs 与机器灌注 (MP) 的结合有望优于传统的保存方法。最近几年，一些研究试图将这种策略用于 SOT，显示出有希望的结果。凭借在离体保存期间更好的器官功能以及利用以前被认为不可移植的器官的潜力，该策略对于器官衰竭患者有助于克服 SOT 领域的器官短缺具有重要意义。