Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines,Organic Chemistry Frontiers

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Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-12-30 , DOI: 10.1039/d0qo01416h
Anan Wang _{1,

2,

3,

4} , Xuesong Liu _{4,

5,

6,

7,

8} , Yi Kong _{1,

2,

3,

4} , Jing Wang _{1,

2,

3,

4} , Tao-Shan Jiang _{1,

2,

3,

4}

Affiliation

A metal-free direct synthesis of pyrimidines from amidine hydrochlorides, ketones and DMSO through substrate-induced DMSO activation and subsequent reactions has been developed. In this protocol, amidine hydrochlorides were not only used as reactants but also activated DMSO to form a sulfenium ion intermediate which then participated in the reactions.

中文翻译：

底物诱导的DMSO活化及随后的反应，可快速构建取代的嘧啶

通过底物诱导的DMSO活化和随后的反应，已开发了由am盐酸盐，酮和DMSO无金属直接合成嘧啶的方法。在该方案中，am盐酸盐不仅用作反应物，而且还可以活化DMSO形成form离子中间体，然后该intermediate离子中间体参与反应。

更新日期：2021-01-12

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