Issue 5, 2021
From the journal:

Organic Chemistry Frontiers

Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines†

Anan Wang,‡a   Xuesong Liu,‡b   Yi Kong,a   Jing Wanga  and  Tao-Shan Jiang ORCID logo *a  

* Corresponding authors

a School of Life Sciences, Anhui Agricultural University, Hefei, P.R. China
E-mail: jts2015@ahau.edu.cn

b Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, P.R. China
E-mail: chemxsliu@126.com

Abstract

A metal-free direct synthesis of pyrimidines from amidine hydrochlorides, ketones and DMSO through substrate-induced DMSO activation and subsequent reactions has been developed. In this protocol, amidine hydrochlorides were not only used as reactants but also activated DMSO to form a sulfenium ion intermediate which then participated in the reactions.

Graphical abstract: Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines

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Article information

DOI
https://doi.org/10.1039/D0QO01416H
Article type
Research Article
Submitted
18 Nov 2020
Accepted
30 Dec 2020
First published
30 Dec 2020

Org. Chem. Front., 2021,8, 947-952

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Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines

A. Wang, X. Liu, Y. Kong, J. Wang and T. Jiang, Org. Chem. Front., 2021, 8, 947 DOI: 10.1039/D0QO01416H

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