Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy,Journal of Materials Chemistry B

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Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-18 , DOI: 10.1039/d0tb02486d
Tianren Xu _{1,

2,

3,

4,

5} , Xiaojiao Zhu _{1,

2,

3,

4,

5} , Li Yang _{1,

2,

3,

4,

5} , Yingcui Bu _{1,

2,

3,

4,

5} , Yuyang Zhang _{1,

2,

3,

4,

5} , Jie Zhang _{5,

6,

7,

8,

9} , Lianke Wang _{5,

6,

7,

8,

9} , Zhipeng Yu _{5,

6,

7,

8,

9} , Hongping Zhou _{1,

2,

3,

4,

5}

Affiliation

Recently, phototherapy has attracted much attention due to its negligible invasiveness, insignificant toxicity and excellent applicability. The construction of a newly proposed nanosystem with synergistic photothermal and photodynamic tumor-eliminating properties requires a delicate structure design. In this work, a novel therapeutic nanoplatform (denoted as BCS-Ce6) based on defective cobalt hydroxide nanosheets was developed, which realized hypoxia-relieved photothermal-enhanced photodynamic therapy against cancer. Defective cobalt hydroxide exhibited high photothermal conversion efficacy at the near-infrared region (49.49% at 808 nm) as well as enhanced catalase-like activity to produce oxygen and greatly boost the singlet oxygen generation by a photosensitizer, Ce6, realizing efficacious dual-modal phototherapy. In vivo and in vitro experiments revealed that BCS-Ce6 can almost completely extinguish implanted tumors in a mouse model and present satisfactory biocompatibility during the treatment. This work sets a new angle of preparing photothermal agents and constructing comprehensive therapeutic nanosystems with the ability to modulate the hypoxic tumor microenvironment for efficient cancer therapy.

中文翻译：

缺氧缓解性缺陷的过渡金属氢氧化物基纳米剂，用于光热增强光动力疗法

近来，光疗法由于其可忽略的侵入性，微不足道的毒性和优异的适用性而引起了广泛的关注。具有协同的光热和光动力消除肿瘤特性的新提出的纳米系统的构建需要精细的结构设计。在这项工作中，开发了一种基于有缺陷的氢氧化钴纳米片的新型治疗性纳米平台（称为BCS-Ce6），实现了针对缺氧的光热增强光动力疗法。缺陷的氢氧化钴在近红外区域（在808 nm处显示49.49％）表现出高的光热转换效率，并增强了过氧化氢酶样生成氧的活性，并大大增强了光敏剂Ce6产生的单线态氧的产生，实现了有效的双峰光疗。体内和体外实验表明，BCS-Ce6几乎可以完全消除小鼠模型中植入的肿瘤，并且在治疗过程中具有令人满意的生物相容性。这项工作为制备光热剂和构建具有调节缺氧肿瘤微环境以进行有效癌症治疗的能力的综合治疗性纳米系统开辟了新的角度。

更新日期：2021-01-12

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