Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy

Tianren Xu; Xiaojiao Zhu; Li Yang; Yingcui Bu; Yuyang Zhang; Jie Zhang; Lianke Wang; Zhipeng Yu; Hongping Zhou

doi:10.1039/D0TB02486D

Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy†

Tianren Xu,^a Xiaojiao Zhu,*^a Li Yang,^a Yingcui Bu,^a Yuyang Zhang,^a Jie Zhang,^b Lianke Wang,

^b Zhipeng Yu^b and Hongping Zhou

*^a

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* Corresponding authors

^a College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, P. R. China
E-mail: xiaojzhu@ahu.edu.cn, zhpzhp@263.net

^b Institute of Physical Science and Information Technology, Faculty of Health Sciences, Anhui University, Hefei, P. R. China

Abstract

Recently, phototherapy has attracted much attention due to its negligible invasiveness, insignificant toxicity and excellent applicability. The construction of a newly proposed nanosystem with synergistic photothermal and photodynamic tumor-eliminating properties requires a delicate structure design. In this work, a novel therapeutic nanoplatform (denoted as BCS-Ce6) based on defective cobalt hydroxide nanosheets was developed, which realized hypoxia-relieved photothermal-enhanced photodynamic therapy against cancer. Defective cobalt hydroxide exhibited high photothermal conversion efficacy at the near-infrared region (49.49% at 808 nm) as well as enhanced catalase-like activity to produce oxygen and greatly boost the singlet oxygen generation by a photosensitizer, Ce6, realizing efficacious dual-modal phototherapy. In vivo and in vitro experiments revealed that BCS-Ce6 can almost completely extinguish implanted tumors in a mouse model and present satisfactory biocompatibility during the treatment. This work sets a new angle of preparing photothermal agents and constructing comprehensive therapeutic nanosystems with the ability to modulate the hypoxic tumor microenvironment for efficient cancer therapy.

This article is part of the themed collection: Journal of Materials Chemistry B HOT Papers

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DOI: https://doi.org/10.1039/D0TB02486D
Article type: Paper
Submitted: 21 Oct 2020
Accepted: 16 Dec 2020
First published: 18 Dec 2020

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J. Mater. Chem. B, 2021,9, 1018-1029

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Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy

T. Xu, X. Zhu, L. Yang, Y. Bu, Y. Zhang, J. Zhang, L. Wang, Z. Yu and H. Zhou, J. Mater. Chem. B, 2021, 9, 1018 DOI: 10.1039/D0TB02486D

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Journal of Materials Chemistry B

Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy†

Abstract

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Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy

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