Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy,Journal of Materials Chemistry B

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Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-11 , DOI: 10.1039/d0tb02410d
Bei Li _{1,

2,

3,

4} , Lan Sun _{4,

5,

6,

7} , Tao Li _{2,

3,

4,

8} , Yingge Zhang _{4,

5,

6,

7} , Xiaoya Niu _{1,

2,

3,

4} , Maodi Xie _{2,

3,

4,

8} , Zhen You _{1,

2,

3,

4}

Affiliation

Gold nanomaterials are widely used in biomedical research as drug delivery systems, imaging agents and therapeutic materials owing to their unique physicochemical properties and high biocompatibility. In this study, we prepared ultra-small gold nanoparticles (AuNPs) and induced them with gadolinium ions to form a spherical self-assembly. The nanoparticles were coupled with matrix metalloproteinase-2 (MMP-2) and loaded with the photosensitive drug IR820 for photothermal/photodynamic combination therapy of liver cancer. The formed nanoprobes were metabolised in vivo via degradation under dual-mode real-time imaging because of their acid response degradation characteristics. In addition, the nanoprobe showed excellent tumour-targeting ability due to the presence of surface-modified MMP-2. In vivo treatment experiments revealed that the nanoprobes achieved enhanced photodynamic/photothermal combination therapy under laser irradiation and significantly inhibited tumour growth. Therefore, the nanoprobes have great potential for anti-tumour therapy guided by dual-mode real-time imaging of liver cancer.

中文翻译：

g离子自组装的超小金纳米颗粒，用于增强光热/光动力肝癌治疗

金纳米材料由于其独特的理化性质和高度的生物相容性而被广泛用于生物医学研究，如药物递送系统，显像剂和治疗材料。在这项研究中，我们制备了超小金纳米颗粒（AuNPs），并用g离子诱导它们形成球形自组装。纳米颗粒与基质金属蛋白酶-2（MMP-2）偶联，并负载有光敏药物IR820，用于肝癌的光热/光动力联合治疗。所形成的纳米探针由于其酸响应降解特性，在双模式实时成像下通过降解在体内代谢。另外，由于存在表面修饰的MMP-2，纳米探针显示出优异的肿瘤靶向能力。体内治疗实验表明，纳米探针在激光照射下实现了增强的光动力/光热联合疗法，并显着抑制了肿瘤的生长。因此，纳米探针在肝癌双模式实时成像指导下具有巨大的抗肿瘤治疗潜力。

更新日期：2021-01-12

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