Issue 4, 2021
From the journal:

Journal of Materials Chemistry B

Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy†

Bei Li,‡a   Lan Sun,‡b   Tao Li,c   Yingge Zhang,b   Xiaoya Niu,a   Maodi Xiec  and  Zhen You ORCID logo *a  

* Corresponding authors

a Department of Biliary Surgery, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China
E-mail: youzhen@wchscu.cn
Fax: +86 028 85423823
Tel: +86 028 85423823

b Key Laboratory of Nanopharmacology and Nanotoxicology, Beijing Institute of Pharmacology and Toxicology, Beijing, China

c West Chia-Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China

Abstract

Gold nanomaterials are widely used in biomedical research as drug delivery systems, imaging agents and therapeutic materials owing to their unique physicochemical properties and high biocompatibility. In this study, we prepared ultra-small gold nanoparticles (AuNPs) and induced them with gadolinium ions to form a spherical self-assembly. The nanoparticles were coupled with matrix metalloproteinase-2 (MMP-2) and loaded with the photosensitive drug IR820 for photothermal/photodynamic combination therapy of liver cancer. The formed nanoprobes were metabolised in vivo via degradation under dual-mode real-time imaging because of their acid response degradation characteristics. In addition, the nanoprobe showed excellent tumour-targeting ability due to the presence of surface-modified MMP-2. In vivo treatment experiments revealed that the nanoprobes achieved enhanced photodynamic/photothermal combination therapy under laser irradiation and significantly inhibited tumour growth. Therefore, the nanoprobes have great potential for anti-tumour therapy guided by dual-mode real-time imaging of liver cancer.

Graphical abstract: Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy

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Supplementary files

Article information

DOI
https://doi.org/10.1039/D0TB02410D
Article type
Paper
Submitted
10 Oct 2020
Accepted
03 Dec 2020
First published
11 Dec 2020

J. Mater. Chem. B, 2021,9, 1138-1150

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Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy

B. Li, L. Sun, T. Li, Y. Zhang, X. Niu, M. Xie and Z. You, J. Mater. Chem. B, 2021, 9, 1138 DOI: 10.1039/D0TB02410D

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