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Standardization and Wound-Healing Activity of Petroleum, Ethanolic and Aqueous Extracts of Ficus Benghalensis Leaves
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2021-01-12 , DOI: 10.1007/s11094-021-02319-x
Mohd Imran , Jyoti Nanda Sharma , Mehnaz Kamal , Mohammad Asif

Wound healing is the repair process of injury on the skin and other soft tissues. After injury, an inflammatory response occurs and tissue cells below the dermis begin to increase collagen formation. Later, the epithelial tissue is regenerated. There are three stages of wound healing process: inflammation, proliferation and remodeling. Traditionally, Ficus benghalensis plant has been used for wound healing but no clear scientific data are available related to this activity. The present work was designed to explore the wound-healing efficacy of petroleum, ethanolic and aqueous extracts of F. benghalensis leaves as evaluated on excision wound models. These leaves extracts were studied for their phytochemicals by means of different chemical tests. Parameters studied include the rate of wound contraction and period of complete epithelialization of incision wound. Student’s t-test was used to analyze the results obtained from this study and confidence level P < 0.05 was considered significant. All the petroleum, ethanolic and aqueous extracts of F. benghalensis leaves were found to possess significant wound-healing activity, which was evidenced by decrease in the period of epithelialization and increase in the rate of wound contraction. The obtained results showed that all extracts of F. benghalensis leaves were capable of accelerated wound-healing activity comparable with a control drug.



中文翻译:

孟加拉榕叶的石油,乙醇和水提取物的标准化和伤口愈合活性

伤口愈合是皮肤和其他软组织受伤的修复过程。受伤后,发生炎症反应,真皮下的组织细胞开始增加胶原蛋白的形成。之后,上皮组织被再生。伤口愈合过程分为三个阶段:炎症,增殖和重塑。传统上,榕榕植物已被用于伤口愈合,但没有与此活动相关的明确科学数据。本工作旨在探讨孟加拉F.的石油,乙醇和水提取物的伤口愈合功效在切除伤口模型上评估叶片。通过不同的化学测试研究了这些叶提取物的植物化学成分。研究的参数包括伤口收缩率和切口伤口完全上皮形成的时间。学生的t检验用于分析从这项研究中获得的结果,置信度P <0.05被认为是显着的。发现孟加拉镰刀菌叶片的所有石油,乙醇和水提取物均具有显着的伤口愈合活性,这由上皮化时期的减少和伤口收缩率的增加证明。获得的结果表明,孟加拉F的所有提取物 与对照药物相比,叶片具有加速的伤口愈合活性。

更新日期:2021-01-12
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