Cyclodextrins, natural oligosaccharides obtained from starch by enzymatic degradation, have been discovered 130 years ago by the pioneering work of the French pharmacist and chemist Antoine Villiers. These molecules still fascinate researchers and industrials because they are remarkable macrocyclic molecules with major impacts in chemistry, biology and health science. When we look at cyclodextrin chemistry today and reflect on how it has developed over the last five decades, no other scientist has been more determining, focused and inspiring than Professor József Szejtli. Indeed, among the list of prestigious researchers who have contributed to the development of cyclodextrins, Professor Szejtli played a fundamental role as an eminent scientist and a visionary. Since the mid-1950s, he has devoted his life to cyclodextrins, publishing more than 500 publications, including 106 patent applications. Professor Szejtli is internationally recognized for his outstanding contribution to the cyclodextrin science and considered to be the “Godfather of Cyclodextrins.” This paper is a tribute to his scientific oeuvre. After a brief overview of his personal life, some important works published by Professor Szejtli in more than fifty years of career were highlighted. For example, he was the first to synthesize the ¹⁴C labeled glucose-based β-cyclodextrin and published his oral metabolism. He was also the first to describe the acid hydrolysis of β-cyclodextrin and discovered that β-cyclodextrin formed inclusion complexes with hydrochloric acid. Professor Szejtli is the founder of International Cyclodextrin Symposia, the first of which was held in 1981 in Budapest.

130年前，法国药剂师和化学家Antoine Villiers的开创性工作发现了环糊精，即通过酶促降解从淀粉中获得的天然低聚糖。这些分子仍然是研究人员和工业界的佼佼者，因为它们是卓越的大环分子，对化学，生物学和健康科学产生重大影响。当我们回顾当今的环糊精化学并反思其在过去五年中的发展时，没有其他科学家比约瑟夫·塞特里教授更坚定，专注和鼓舞人心。的确，在为环糊精的发展做出贡献的著名研究人员中，塞兹特利教授作为杰出的科学家和有远见的科学家发挥了根本作用。自1950年代中期以来，他一直致力于环糊精，出版500多种出版物，包括106项专利申请。Szejtli教授以其对环糊精科学的杰出贡献而享誉国际，被誉为“环糊精的教父”。这篇论文是对他的科学著作的致敬。在简要概述了他的个人生活后，重点介绍了塞格特利教授在其五十多年的职业生涯中出版的一些重要作品。例如，他是第一个合成 重点介绍了塞格特利教授在其五十多年的职业生涯中发表的一些重要著作。例如，他是第一个合成 重点介绍了塞格特利教授在其五十多年的职业生涯中发表的一些重要著作。例如，他是第一个合成¹⁴ C标记了基于葡萄糖的β-环糊精并发表了他的口服代谢信息。他也是第一个描述β-环糊精酸水解的人，并发现β-环糊精与盐酸形成了包合物。Szejtli教授是国际环糊精研讨会的创始人，该研讨会于1981年在布达佩斯举行。