The lysosome represents an important regulatory platform within numerous vesicle trafficking pathways including the endocytic, phagocytic, and autophagic pathways. Its ability to fuse with endosomes, phagosomes, and autophagosomes enables the lysosome to break down a wide range of both endogenous and exogenous cargo, including macromolecules, certain pathogens, and old or damaged organelles. Due to its center position in an intricate network of trafficking events, the lysosome has emerged as a central signaling node for sensing and orchestrating the cells metabolism and immune response, for inter-organelle and inter-cellular signaling and in membrane repair. This review highlights the current knowledge of general lysosome function and discusses these findings in their implication for renal glomerular cell types in health and disease including the involvement of glomerular cells in lysosomal storage diseases and the role of lysosomes in nongenetic glomerular injuries.

中文翻译：

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溶酶体在肾小球健康和疾病中的功能

溶酶体代表了许多囊泡运输途径中的重要调节平台，包括内吞、吞噬和自噬途径。它与内体、吞噬体和自噬体融合的能力使溶酶体能够分解各种内源性和外源性货物，包括大分子、某些病原体以及旧的或受损的细胞器。由于其在复杂的运输事件网络中的中心位置，溶酶体已成为传感和协调细胞代谢和免疫反应、细胞器间和细胞间信号以及膜修复的中心信号节点。