Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process,Organic Chemistry Frontiers

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Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-12-21 , DOI: 10.1039/d0qo01269f
Qingsong Deng _{1,

2,

3,

4,

5} , Aimin Yu _{1,

2,

3,

4,

5} , Shunguang Zhang _{1,

2,

3,

4,

5} , Xiangtai Meng _{1,

2,

3,

4,

5}

Affiliation

A K₂CO₃-promoted tunable domino reaction between thioisatins and α-bromoketones was developed for the synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via adjusting MgSO₄. The reaction proceeds via K₂CO₃-induced C–S bond cleavage followed by two-step condensation reactions. The significance of these novel domino reactions lies in the formation of the products that are not easily accessible via traditional synthetic methods.

中文翻译：

通过多米诺法可调谐合成苯并噻吩稠合的吡喃酮和硫代色素稠合的呋喃衍生物

开发了AK ₂ CO ₃促进的巯基异丁烯与α-溴酮之间的可调多米诺反应，通过调节MgSO ₄合成苯并噻吩稠合的吡喃酮和硫色素稠合的呋喃衍生物。该反应通过K ₂ CO ₃诱导的C–S键断裂进行，然后进行两步缩合反应。这些新颖的多米诺骨牌反应的重要性在于通过传统的合成方法难以获得的产物的形成。

更新日期：2021-01-11

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