Issue 5, 2021
From the journal:

Organic Chemistry Frontiers

Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process†

Qingsong Deng,a   Aimin Yu,a   Shunguang Zhanga  and  Xiangtai Meng ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China
E-mail: mengxiangtai23@mail.nankai.edu.cn

Abstract

A K2CO3-promoted tunable domino reaction between thioisatins and α-bromoketones was developed for the synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via adjusting MgSO4. The reaction proceeds via K2CO3-induced C–S bond cleavage followed by two-step condensation reactions. The significance of these novel domino reactions lies in the formation of the products that are not easily accessible via traditional synthetic methods.

Graphical abstract: Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process

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Article information

DOI
https://doi.org/10.1039/D0QO01269F
Article type
Research Article
Submitted
13 Oct 2020
Accepted
19 Dec 2020
First published
21 Dec 2020

Org. Chem. Front., 2021,8, 936-940

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Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process

Q. Deng, A. Yu, S. Zhang and X. Meng, Org. Chem. Front., 2021, 8, 936 DOI: 10.1039/D0QO01269F

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