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Nanostructured Porous Silicon Containers as Drug Carriers
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2021-01-01 , DOI: 10.1007/s11094-021-02320-4
A. A. Belogorlov , S. A. Bortnikova , A. G. Akopdzhanov , N. L. Shimanovsky

The possibilities of using porous silicon nanostructured containers as drug carriers are considered. The main design principles of the nanocontainers and the possibility of using pore surface modification to achieve the optimal regimes of drug loading and controlled in vivo drug release are formulated. Results from studies devoted to the application of porous silica containers are presented. The main prospects and research tasks in this field are related to reducing the object size, increasing the biocompatibility, increasing the drug loading volume, and achieving the optimal drug release kinetics.

中文翻译:

纳米结构多孔硅容器作为药物载体

考虑了使用多孔硅纳米结构容器作为药物载体的可能性。制定了纳米容器的主要设计原则和使用孔表面修饰实现药物装载和控制体内药物释放的最佳方案的可能性。介绍了专门用于多孔二氧化硅容器应用的研究结果。该领域的主要前景和研究任务涉及减小物体尺寸、增加生物相容性、增加载药量和实现最佳药物释放动力学。
更新日期:2021-01-01
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