Skip to main content

Advertisement

SpringerLink
Log in

Nanostructured Porous Silicon Containers as Drug Carriers

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The possibilities of using porous silicon nanostructured containers as drug carriers are considered. The main design principles of the nanocontainers and the possibility of using pore surface modification to achieve the optimal regimes of drug loading and controlled in vivo drug release are formulated. Results from studies devoted to the application of porous silica containers are presented. The main prospects and research tasks in this field are related to reducing the object size, increasing the biocompatibility, increasing the drug loading volume, and achieving the optimal drug release kinetics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. D. Shaikhutdinova, T. F. Shaikhutdinov, A. G. Akopdzhanov, et al., Ross Nanotekhnol., 13(5 – 6), 103 – 107 (2018).

    Google Scholar 

  2. A. G. Akopdzhanov, N. L. Shimanovskii, A. I. Borisova, et al., Eksp. Klin. Farmakol., 80(9), 58 – 61 (2017).

    CAS  Google Scholar 

  3. J. Jeevanandam, A. Barhoum, Y. S. Chan, et al., Beilstein J. Nanotechnol., 9(1), 1050 – 1074 (2018).

    Article  CAS  Google Scholar 

  4. N. Iturrioz-Rodriguez, M. A. Correa-Duarte, and M. I. Fanarrage, Int. J. Nanomed., 14, 3398 – 3401 (2019).

    Article  Google Scholar 

  5. O. I. Ksenofontova, A. V. Vasin, V. V. Egorov, et al., Zh. Tekh. Fiz., 84(1), 67 – 78 (2014).

    Google Scholar 

  6. E. V. Astrova, V. P. Ulin, Y. A. Zharova, et al., J. Electrochem. Soc., 159(3), 172 – 180 (2012).

    Article  Google Scholar 

  7. G. V. Lisichkin, Chemistry of Grafted Surface Compounds [in Russian], Fizmatlit, Moscow (2003).

    Google Scholar 

  8. V. D. Borman, A. A. Belogorlov, and V. N. Tronin, Colloids. Surf., A, 496, 63 – 68 (2016).

    Article  CAS  Google Scholar 

  9. V. D. Borman, A. A. Belogorlov, A. M. Grekhov, et al., Zh. Eksp. Teor. Fiz., 127(2), 431 – 444 (2005).

    Google Scholar 

  10. P. G. Mingalev and G. V. Lisichkin, Usp. Khim., 75(6), 604 – 624 (2006).

    Google Scholar 

  11. C. V. Suciu, Y. Kimura, and S. Tani, Adv. Mat. Res., 123 – 125, 1003 – 1006 (2010), J. H. Lee (ed.).

  12. M. Catauro and S. V. Ciprioti, in: Thermodynamics and Biophysics of Biomedical Nanosystems, C. Demetzos and N. Pippa (eds.), Springer Nature Singapore Pte Ltd., Singapore (2019), pp. 445 – 475.

    Chapter  Google Scholar 

  13. R. E. Serda, S. Ferrati, B. Godin, et al., Nanoscale, 1, 250 – 259 (2009).

    Article  CAS  Google Scholar 

  14. Q. Shabir, K. Webb, D. K. Nadarassan, et al., Silicon, 10, 349 – 359 (2018).

    Article  CAS  Google Scholar 

  15. V. M. Petriev, V. K. Tischenko, A. A. Mikhailovskaya, et al., Sci. Rep., 9, 2017 – 1–2017 – 10 (2019).

  16. D. Chen, N. Hao, H. Liu, et al., J. Nanosci. Nanotechnol., 12, 6346 – 6354 (2012).

    Article  Google Scholar 

  17. X. Huang, N. Young, and H. Townley, Nanomater. Nanotechnol., 4(22), 1 – 10 (2014).

    Google Scholar 

  18. J. Paris, M. Cabacas, and M. Manzano, ACS Nano, 9(11), 11023 – 11033 (2015).

    Article  CAS  Google Scholar 

  19. R. Roggers, M. Joglekar, J Valenstein, and B. Trewyn, ACS Appl. Mater. Interfaces, 6(3), 1675 – 1681 (2014).

    Article  CAS  Google Scholar 

  20. J. Lu, Z. Li, J. Zink, and F. Tamanoi, Nanomed.: Nanotechnol., Biol. Med., 28(2), 21 – 27 (2012).

    CAS  Google Scholar 

  21. E. Tolstik, L. A. Osminkina, C. Matthaus, et al., Nanotechnol., Biol. Med., 12(7), 1931 – 1940 (2016).

    Article  CAS  Google Scholar 

  22. R. E. Serda, J. Gu, R. C. Bhavane, X. W. Liu, et al., Biomaterials., 30, 2440 – 2448 (2009).

    Article  CAS  Google Scholar 

  23. V. Onesto, M. Villani, and M. Coluccio, Nanoscale Res. Lett., 13, 1886 – 1895 (2018).

    Article  Google Scholar 

  24. Y. Zhu, J. Shi, W. Shen, et al., Angew. Chem., Int. Ed., 44, 5083 – 5087 (2005).

    Google Scholar 

  25. A. Tzur-Balter, Z. Shatsberg, M. Beckerman, et al., Nat. Commun., 6, 6208 – 6216 (2015).

    Article  CAS  Google Scholar 

  26. Q. He, Z. Zhang, F. Gao, et al., Small, 7, 271 – 280 (2011).

    Article  CAS  Google Scholar 

  27. H. Meng, M. Xue, T. Xia, and Z. Ji, ACS Nano, 5, 4131 – 4344 (2011).

    Article  CAS  Google Scholar 

  28. A. G. Kuz’min, D. V. Lipatov, and O. M. Smirnova, Oftal’mokhirurgiya, 3, 11 – 16 (2009).

    Google Scholar 

  29. Yu. A. Polkovnikova, Biofarm. Zh., 9(2), 43 – 49 (2017).

    CAS  Google Scholar 

  30. L. Gholami, M. Tafaghodi, B. Abbasi, et al., J. Cell. Physiol., 234(2), 1547 – 1559 (2019).

    Article  CAS  Google Scholar 

  31. J.-H. Park, L. Gu, G. von Maltzahn, E. Ruoslahti, et al., Nat. Mater., 8, 331 – 336 (2009).

    Article  CAS  Google Scholar 

  32. Y.Wei, L. Gao, L.Wang, et al., Drug Delivery, 24(1), 681 – 685 (2017).

    Article  CAS  Google Scholar 

  33. L. Xiaowei, Z. Wenru, L. Xiaohang, et al., Acta Biomater., 30, 378 – 387 (2016).

    Article  Google Scholar 

  34. Y. V. Kargina, A. M. Perepukhov, A. Yu. Kharin, et al., Phys. Status Solidi A, 216(14), 1800897 – 1800911 (2019).

    Article  Google Scholar 

  35. B. Kim, S. Sun, and J. A. Varner, Adv. Mater., 31(35), 1902952 – 1902963 (2019).

    Article  Google Scholar 

  36. J.-G. Sun, Q. Jiang, and X.-P. Zhang, Int. J. Nanomed., 14, 1489 – 1501 (2019).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The work was financially supported by the RFBR in the framework of Science Project No. 19-08-01140.

Author information

Authors and Affiliations

  1. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, Moscow, 115409, Russia

    A. A. Belogorlov & S. A. Bortnikova

  2. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29/2 Leninskii Prosp, Moscow, 119991, Russia

    A. A. Belogorlov & S. A. Bortnikova

  3. N. I. Pirogov Russian National Research Medical University, 1 Ostrovityanova St, Moscow, 117997, Russia

    A. G. Akopdzhanov & N. L. Shimanovsky

Authors
  1. A. A. Belogorlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. A. Bortnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. G. Akopdzhanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. L. Shimanovsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Belogorlov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 10, pp. 47 – 51, October, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Belogorlov, A.A., Bortnikova, S.A., Akopdzhanov, A.G. et al. Nanostructured Porous Silicon Containers as Drug Carriers. Pharm Chem J 54, 1063–1066 (2021). https://doi.org/10.1007/s11094-021-02320-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-021-02320-4

Keywords

Search

Navigation