The epigenome involves a complex set of cellular processes governing genomic activity. Dissecting this complexity necessitates the development of tools capable of specifically manipulating these processes. The repurposing of prokaryotic CRISPR systems has allowed for the development of diverse technologies for epigenome engineering. Here, we review the state of currently achievable epigenetic manipulations along with corresponding applications. With future optimization, CRISPR-based epigenomic editing stands as a set of powerful tools for understanding and controlling biological function.

中文翻译：

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用于精确表观基因组编辑的 CRISPR 技术

表观基因组涉及一组控制基因组活动的复杂细胞过程。剖析这种复杂性需要开发能够专门操纵这些过程的工具。原核 CRISPR 系统的再利用允许开发用于表观基因组工程的多种技术。在这里，我们回顾了当前可实现的表观遗传操作的状态以及相应的应用。随着未来的优化，基于 CRISPR 的表观基因组编辑将成为一套用于理解和控制生物功能的强大工具。