The synthesis of block copolymers of poly(tetrahydrofuran)-b-poly(a-amino acid) (PTHF-b-PAA) is challenging since it is difficult to combine the two blocks produced via different/conflicting ring-opening polymerization (ROP) mechanisms. In this contribution, the cationic ROP of THF is catalyzed by rare-earth triflate [RE(OTf)₃] and terminated by 2-(t-butyloxycarbonyl-amino) ethanol (BAE). After the deprotection of t-butyloxycarbonyl (Boc) group, the chain end of PTHF is quantitatively changed to amino group which thereafter initiates the nucleophilic ROP of a-amino acid N-thiocarboxyanhydrides (NTAs). Both polymerizations are well controlled, generating PTHF and PAA segments with designable molecular weights (MWs). PTHF-b-polylysine (PTHF-b-PLys) and PTHF-b-polysarcosine (PTHF-b-PSar) are obtained with MWs between 8.6 and 28.7 kg/mol. The above amphiphilic diblock copolymers form micelles in water. PTHF₄₀-b-PSar₃₂ acts as a surfactant to stabilize oil-in-water emulsions. Both segments of PTHF-b-PAA are biocompatible and promising in the biomedical application.

聚的嵌段共聚物的合成（四氢呋喃） - b -聚（一个氨基酸）（PTHF- b -PAA）是具有挑战性的，因为它是难以生产的两个块合并通过不同/冲突的开环聚合（ROP）机制。在这种贡献中，THF的阳离子ROP被稀土三氟甲磺酸盐[RE（OTf）₃ ]催化，并被2-（叔丁氧羰基氨基）乙醇（BAE）终止。的脱保护后吨丁氧基羰（Boc）基团，PTHF的链端定量改变为氨基其中此后发起的亲核ROP一个α-氨基酸Ñ-硫代羧酸酐（NTA）。两种聚合均受到良好控制，生成具有可设计分子量（MWs）的PTHF和PAA链段。获得MW为8.6至28.7kg / mol的PTHF- b-聚赖氨酸（PTHF- b- PLys）和PTHF- b-聚肌氨酸（PTHF- b- PSar）。上述两亲性二嵌段共聚物在水中形成胶束。PTHF ₄₀ - b -PSar ₃₂用作表面活性剂以稳定水包油乳液。PTHF- b- PAA的两个片段都是生物相容的，在生物医学应用中很有前途。