Resveratrol (RV) is a polyphenolic compound with antioxidant, anti-inflammatory, and hypoglycemic properties. Several in vitro and animal model studies have demonstrated the beneficial effects of RV; however, the results in humans are not conclusive. After a search of different databases, 32 studies were selected for this systematic review and 30 were included in the meta-analysis. Studies that evaluated the effect of RV on glucose, insulin, HbA1c, and insulin resistance (HOMA-IR) levels were included. A significant decrease of glucose (−5.24 mg/dL, p = 0.002) and insulin levels (−1.23 mIU/L, p = 0.0003) was observed. HbA1c and HOMA-IR did not show significant changes. Due to heterogeneity, sub-analyzes were performed. Sub-analysis by dose revealed that glucose levels improve significantly after the administration of 500–1000 mg/day of RV (−7.54 mg/dL, p = 0.002), while insulin improves with doses lower than 500 mg/day (−1.43 mIU/L, p = 0.01) and greater than 1000 mg/day (−2.12 mIU/L, p = 0.03). HbA1c and HOMA-IR remained unchanged after sub-analysis by dose. Our findings suggest that RV improves glucose and insulin levels in subjects with type 2 diabetes mellitus (T2DM) and aged 45–59 years, regardless of the duration of the intervention. HbA1c improves with interventions ≥3 months. HOMA-IR does not exhibit significant changes after RV administration.

中文翻译：

---

白藜芦醇的降血糖作用：系统评价和荟萃分析


白藜芦醇 (RV) 是一种多酚化合物，具有抗氧化、抗炎和降血糖特性。多项体外和动物模型研究已经证明了 RV 的有益作用；然而，在人类身上的结果并不是决定性的。经过对不同数据库的检索，本次系统评价选择了 32 项研究，其中 30 项纳入荟萃分析。其中包括评估 RV 对葡萄糖、胰岛素、HbA1c 和胰岛素抵抗 (HOMA-IR) 水平影响的研究。观察到葡萄糖（−5.24 mg/dL， p = 0.002）和胰岛素水平（−1.23 mIU/L， p = 0.0003）显着下降。 HbA1c 和 HOMA-IR 没有显示显着变化。由于异质性，进行了子分析。按剂量进行的子分析显示，服用 500–1000 mg/天的 RV 后，血糖水平显着改善（−7.54 mg/dL， p = 0.002），而胰岛素剂量低于 500 mg/天时会改善（−1.43 mIU） /L， p = 0.01）且大于 1000 mg/天（−2.12 mIU/L， p = 0.03）。按剂量进行亚分析后，HbA1c 和 HOMA-IR 保持不变。我们的研究结果表明，无论干预时间长短，RV 都能改善 45-59 岁 2 型糖尿病 (T2DM) 受试者的血糖和胰岛素水平。干预≥3 个月后，HbA1c 会有所改善。 RV 给药后 HOMA-IR 没有表现出显着变化。