Cold atmospheric pressure plasmas (CAPPs) increasingly attracted scientific attention in the field of medicine, especially oncology. Because of the surface action of CAPPs, treatment of skin cancers appears to be one of the most promising CAPP applications. This novel controlled CAPP application in the cancer treatment is associated with the selective anticancer characteristics of CAPP. In this literature review, the latest achievements in the field of plasma medicine related to effects of CAPP on the skin cancers were presented. Additionally, typical methods for CAPP generation and application towards skin cancer models were discussed. For a better understanding of complex interactions between reactive species (generated during CAPP operation) and cellular components, biological processes in various experimental models were analyzed. Furthermore, biological impacts of reactive oxygen species and reactive nitrogen species on skin cancer models was evaluated. Finally, prospects for receiving a clinically applicable product and cooperating with conventional therapies or drugs used in skin cancer management were debated.

中文翻译：

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冷大气压等离子体对皮肤癌的生物学效应

冷常压等离子体 (CAPP) 越来越引起医学领域的科学关注，尤其是肿瘤学。由于 CAPP 的表面作用，皮肤癌的治疗似乎是最有前途的 CAPP 应用之一。这种新型受控 CAPP 在癌症治疗中的应用与 CAPP 的选择性抗癌特性有关。在这篇文献综述中，介绍了与 CAPP 对皮肤癌的影响相关的血浆医学领域的最新成果。此外，还讨论了 CAPP 生成和应用于皮肤癌模型的典型方法。为了更好地理解活性物质（在 CAPP 操作期间产生）和细胞成分之间的复杂相互作用，分析了各种实验模型中的生物过程。此外，评估了活性氧和活性氮对皮肤癌模型的生物学影响。最后，对获得临床适用产品和与用于皮肤癌治疗的常规疗法或药物合作的前景进行了辩论。