Lower sepsis mortality rates imply that more patients are discharged from the hospital, but sepsis survivors often experience sequelae, such as functional disability, cognitive impairment, and psychiatric morbidity. Nevertheless, the mechanisms underlying these long-term disabilities are not fully understood. Considering the extensive use of animal models in the study of the pathogenesis of neuropsychiatric disorders, it seems adopting this approach to improve our knowledge of postseptic psychiatric symptoms is a logical approach. With the purpose of gathering and summarizing the main findings of studies using animal models of sepsis-induced psychiatric symptoms, we performed a systematic review of the literature on this topic. Thus, 140 references were reviewed, and most of the published studies suggested a time-dependent recovery from behavior alterations, despite the fact that some molecular alterations persist in the brain. This review reveals that animal models can be used to understand the mechanisms that underlie anxiety and depression in animals recovering from sepsis.

脓毒症死亡率较低意味着更多患者可以出院，但脓毒症幸存者经常会出现后遗症，例如功能障碍、认​​知障碍和精神疾病。然而，这些长期残疾的机制尚不完全清楚。考虑到动物模型在神经精神疾病发病机制研究中的广泛使用，采用这种方法来提高我们对脓毒症后精神症状的了解似乎是一种合乎逻辑的方法。为了收集和总结使用脓毒症引起的精神症状动物模型进行的研究的主要结果，我们对有关该主题的文献进行了系统回顾。因此，我们回顾了 140 篇参考文献，大多数已发表的研究表明，行为改变的恢复具有时间依赖性，尽管事实上某些分子改变在大脑中持续存在。这篇综述表明，动物模型可用于了解从败血症中恢复的动物焦虑和抑郁的机制。