当前位置：
X-MOL 学术
›
J. Mater. Chem. B
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-7 , DOI: 10.1039/d0tb02423f Miao Sun 1, 2, 3, 4, 5 , Huifeng Shao 5, 6, 7, 8, 9 , Haibin Xu 10, 11, 12, 13, 14 , Xiaofu Yang 1, 2, 3, 4, 5 , Mingyi Dong 1, 2, 3, 4, 5 , Jiaxing Gong 1, 2, 3, 4, 5 , Mengfei Yu 1, 2, 3, 4, 5 , Zhongru Gou 5, 13, 15, 16, 17 , Yong He 5, 6, 9, 13, 18 , An Liu 10, 11, 12, 13, 14 , Huiming Wang 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-7 , DOI: 10.1039/d0tb02423f Miao Sun 1, 2, 3, 4, 5 , Huifeng Shao 5, 6, 7, 8, 9 , Haibin Xu 10, 11, 12, 13, 14 , Xiaofu Yang 1, 2, 3, 4, 5 , Mingyi Dong 1, 2, 3, 4, 5 , Jiaxing Gong 1, 2, 3, 4, 5 , Mengfei Yu 1, 2, 3, 4, 5 , Zhongru Gou 5, 13, 15, 16, 17 , Yong He 5, 6, 9, 13, 18 , An Liu 10, 11, 12, 13, 14 , Huiming Wang 1, 2, 3, 4, 5
Affiliation
|
About 10 million fractures occur worldwide each year, of which more than 60% are long bone fractures. It is generally agreed that intramedullary nails have significant advantages in rigid fracture fixation. Metal intramedullary nails (INs) can provide strong support but a stress shielding effect can occur that results in nonunion healing in clinic. Nondegradable metals also need to be removed by a second operation. Could INs be biodegradable and used to overcome this issue? As current degradable biomaterials always suffer from low strength and cannot be used in Ins, herein, we report a novel device consisting of biodegradable IN (BIN) made for the first time with bioceramics. These BINs have an extremely high bending strength and stable internal and external structure. Experiments show that the BINs could not only fix and support the tibial fracture model, but also promote osteogenesis and affect the microenvironment of the bone marrow cavity. Therefore, they could be expected to replace traditional metal IN and become a more effective treatment option for tibial fractures.
中文翻译：
具有高强度生物陶瓷的可生物降解的髓内钉（BIN）用于骨折
全世界每年大约发生一千万个骨折，其中超过60％是长骨骨折。通常认为，髓内钉在刚性骨折固定中具有明显的优势。金属髓内钉（INs）可以提供强大的支撑力，但是会产生应力屏蔽效果，从而在临床上导致骨不愈合。不可降解的金属也需要通过第二次操作去除。IN可以生物降解并用于克服此问题吗？由于当前的可降解生物材料总是强度低并且不能在Ins中使用，因此，本文报道了一种由生物陶瓷首次制成的可生物降解的IN（BIN）组成的新型设备。这些BIN具有极高的弯曲强度以及稳定的内部和外部结构。实验表明，BINs不仅可以固定和支持胫骨骨折模型，而且可以促进成骨作用并影响骨髓腔的微环境。因此，可以预期它们将替代传统的金属IN并成为胫骨骨折更有效的治疗选择。
更新日期：2021-01-06
中文翻译：
具有高强度生物陶瓷的可生物降解的髓内钉（BIN）用于骨折
全世界每年大约发生一千万个骨折，其中超过60％是长骨骨折。通常认为，髓内钉在刚性骨折固定中具有明显的优势。金属髓内钉（INs）可以提供强大的支撑力，但是会产生应力屏蔽效果，从而在临床上导致骨不愈合。不可降解的金属也需要通过第二次操作去除。IN可以生物降解并用于克服此问题吗？由于当前的可降解生物材料总是强度低并且不能在Ins中使用，因此，本文报道了一种由生物陶瓷首次制成的可生物降解的IN（BIN）组成的新型设备。这些BIN具有极高的弯曲强度以及稳定的内部和外部结构。实验表明，BINs不仅可以固定和支持胫骨骨折模型，而且可以促进成骨作用并影响骨髓腔的微环境。因此，可以预期它们将替代传统的金属IN并成为胫骨骨折更有效的治疗选择。
京公网安备 11010802027423号