Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture

Miao Sun; Huifeng Shao; Haibin Xu; Xiaofu Yang; Mingyi Dong; Jiaxing Gong; Mengfei Yu; Zhongru Gou; Yong He; An Liu; Huiming Wang

doi:10.1039/D0TB02423F

Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture†

Miao Sun,

‡^a Huifeng Shao,‡^bcde Haibin Xu,‡^f Xiaofu Yang,

^a Mingyi Dong,^a Jiaxing Gong,

^a Mengfei Yu,

^a Zhongru Gou,^e Yong He,

*^cd An Liu*^f and Huiming Wang*^a

Author affiliations

* Corresponding authors

^a The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang, China
E-mail: whmwhm@zju.edu.cn

^b School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China

^c State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: yongqin@zju.edu.cn

^d Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China

^e Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China

^f Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
E-mail: la@zju.edu.cn

Abstract

About 10 million fractures occur worldwide each year, of which more than 60% are long bone fractures. It is generally agreed that intramedullary nails have significant advantages in rigid fracture fixation. Metal intramedullary nails (INs) can provide strong support but a stress shielding effect can occur that results in nonunion healing in clinic. Nondegradable metals also need to be removed by a second operation. Could INs be biodegradable and used to overcome this issue? As current degradable biomaterials always suffer from low strength and cannot be used in Ins, herein, we report a novel device consisting of biodegradable IN (BIN) made for the first time with bioceramics. These BINs have an extremely high bending strength and stable internal and external structure. Experiments show that the BINs could not only fix and support the tibial fracture model, but also promote osteogenesis and affect the microenvironment of the bone marrow cavity. Therefore, they could be expected to replace traditional metal IN and become a more effective treatment option for tibial fractures.

$Graphical abstract: Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture$

Journal of Materials Chemistry B

Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture†

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Biodegradable intramedullary nail (BIN) with high-strength bioceramics for bone fracture

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