Several studies have reported that probiotics could modulate host lipid metabolism via altering the intestinal microbiota. Hence, the current study was aimed to assess the efficacy of a mixture of probiotic-contained milk formula (PMF) with three different bacterial strains [Lactobacillus acidophilus (La5), Lactobacillus casei (TMC), Bifidobacterium lactis (Bb12)] on lipid profile and intestinal function in healthy mild hypercholesterolemic volunteers. Totally, 40 healthy mild hypercholesterolemic subjects (180–220 mg/dL) were randomly assigned into two groups as placebo or experimental group. All the subjects were requested to drink either PMF (experimental) or skimmed milk drink formula-placebo (30 g mixed with 200 mL of water) for 10 weeks and continued by 2 weeks of the follow-up period. Supplementation of PMF for 10 weeks significantly improved (p < 0.05) the fecal weight, fecal movement (decreased fecal gastrointestinal passing time) by improving intestinal microbiota (increasing beneficial bacterial species like Lactobacillus, Bifidobacterium spp.), and lag time of low-density lipoprotein (LDL) oxidation. Also, intake of PMF substantially reduced (p < 0.05) the levels of total cholesterol (TC; 8.1%) and low-density lipoprotein cholesterol (LDL-c; 10.4%) and thus showcasing its cardioprotective efficacy. PMF considerably improves gastrointestinal function by modulating fecal movement, intestinal microbiota, and decrease cholesterol and might be helpful in the management of hypercholesterolemia.

几项研究报告称，益生菌可以通过改变肠道微生物群来调节宿主脂质代谢。因此，本研究旨在评估含益生菌配方奶粉 (PMF) 与三种不同细菌菌株 [嗜酸乳杆菌(La5)、干酪乳杆菌(TMC)、乳酸双歧杆菌( Bifidobacterium lactis )] 的功效。(Bb12)] 对健康轻度高胆固醇血症志愿者的血脂和肠道功能的影响。总共有 40 名健康的轻度高胆固醇血症受试者 (180-220 mg/dL) 被随机分配到两组作为安慰剂组或实验组。要求所有受试者饮用 PMF（实验性）或脱脂乳饮料配方-安慰剂（30 克与 200 毫升水混合）10 周，并持续到 2 周的随访期。补充 PMF 10 周 通过改善肠道微生物群（增加乳酸杆菌、双歧杆菌等有益细菌种类）显着改善（p < 0.05）粪便重量、粪便运动（减少粪便通过胃肠道的时间）spp.)，以及低密度脂蛋白 (LDL) 氧化的滞后时间。此外，PMF 的摄入显着降低 ( p  < 0.05) 总胆固醇 (TC; 8.1%) 和低密度脂蛋白胆固醇 (LDL-c; 10.4%) 的水平，从而显示其心脏保护功效。PMF 通过调节粪便运动、肠道微生物群和降低胆固醇显着改善胃肠道功能，并可能有助于控制高胆固醇血症。