The addition of magnetic nanoparticles gives unique properties to hydrogels. Magnetic-sensitive gels have various applications in targeted drug delivery, separation, and sensing. One of the most advantageous aspects of using magnetic nanoparticles is their ability to respond to remote control by an external magnetic field. Microgels loaded with magnetic nanoparticles enhance control in magnetic resonance imaging. In addition, these materials change the rate of hydrogel swelling in the magnetic field. In this study, we report a novel type of magnetite nanocomposite based on poly (acrylamide-co-acrylic acid) hydrogel by simple, cost effective, and eco-friendly process in a viscous medium containing glycerol at room temperature. For this purpose, first, Fe₃O₄ nanoparticles were synthesized through sedimentation process. The final nanocomposite was efficiently obtained in a short reaction time under ultrasonic irradiation at room temperature and the absence of chemical initiator. The SEM images show a uniform distribution of Fe₃O₄ nanoparticles in the hydrogel matrix with a morphology similar to cubic crystalline lattices. The swelling behavior of the prepared magnetite nanocomposites were investigated in three different mediums and showed a fast initial swelling followed by a mild increase until attaining equilibrium. The highest and the lowest swelling was obtained in pure water and under pressure, respectively. Also, the absorption and release of two drugs, fluvoxamine and ciprofloxacin, were studied in a phosphate buffer solution at 37 °C to investigate the efficiency of entitled sonochemical prepared hydrogel nanocomposite in drug delivery field.

磁性纳米粒子的添加赋予水凝胶独特的性能。磁敏凝胶在靶向药物的输送，分离和传感方面具有多种应用。使用磁性纳米颗粒的最有利方面之一是其响应外部磁场对远程控制的能力。装有磁性纳米颗粒的微凝胶可增强磁共振成像的控制能力。另外，这些材料改变了水凝胶在磁场中的膨胀速率。在这项研究中，我们报告了一种新型的磁铁矿纳米复合材料，它是在室温下在含有甘油的粘性介质中，通过简单，经济高效且环保的工艺，基于聚（丙烯酰胺-丙烯酸）水凝胶制成的。为此，首先是Fe ₃ O ₄通过沉淀过程合成了纳米颗粒。在室温下在超声辐射下且不存在化学引发剂的情况下，在短的反应时间内有效地获得了最终的纳米复合材料。SEM图像显示出Fe ₃ O ₄的均匀分布水凝胶基质中的纳米颗粒具有类似于立方晶格的形态。在三种不同的介质中研究了制备的磁铁矿纳米复合材料的溶胀行为，并显示出快速的初始溶胀，然后缓慢增加直至达到平衡。在纯水中和在压力下分别获得最高和最低的溶胀。另外，在37°C的磷酸盐缓冲溶液中研究了氟伏沙明和环丙沙星这两种药物的吸收和释放，以研究标题为声化学制备的水凝胶纳米复合材料在药物输送领域的效率。