Abstract
The addition of magnetic nanoparticles gives unique properties to hydrogels. Magnetic-sensitive gels have various applications in targeted drug delivery, separation, and sensing. One of the most advantageous aspects of using magnetic nanoparticles is their ability to respond to remote control by an external magnetic field. Microgels loaded with magnetic nanoparticles enhance control in magnetic resonance imaging. In addition, these materials change the rate of hydrogel swelling in the magnetic field. In this study, we report a novel type of magnetite nanocomposite based on poly (acrylamide-co-acrylic acid) hydrogel by simple, cost effective, and eco-friendly process in a viscous medium containing glycerol at room temperature. For this purpose, first, Fe3O4 nanoparticles were synthesized through sedimentation process. The final nanocomposite was efficiently obtained in a short reaction time under ultrasonic irradiation at room temperature and the absence of chemical initiator. The SEM images show a uniform distribution of Fe3O4 nanoparticles in the hydrogel matrix with a morphology similar to cubic crystalline lattices. The swelling behavior of the prepared magnetite nanocomposites were investigated in three different mediums and showed a fast initial swelling followed by a mild increase until attaining equilibrium. The highest and the lowest swelling was obtained in pure water and under pressure, respectively. Also, the absorption and release of two drugs, fluvoxamine and ciprofloxacin, were studied in a phosphate buffer solution at 37 °C to investigate the efficiency of entitled sonochemical prepared hydrogel nanocomposite in drug delivery field.
Similar content being viewed by others
References
Yinjuan H, Mingzhu L, Jiucun C, Chunmei G, Qiuyu G (2012) A Novel Magnetic Triple-Rresponsive Composite Semi-IPN Hydrogels for Targeted and Controlled Drug Delivery. Eur Polym J 48:1734–1744
Tiwari A (2011) Recent Developments in Bio-Nanocomposites for Biomedical Applications. NewYork Nova Science Publishers 17–18
Shapiro JM, Oyen ML (2013) Hydrogel Composite Materials for Tissue Engineering Scaffold. J Minerals 65:505–516
Nam JA, AlN A, Hong S, Lee KD, Lee H, Park SY (2011) Synthesis and Characterization of a Multi-sensitive Crosslinked Injectable Hydrogel Based on Pluronic. Macromol Biosci 11:1594–1602
Tan L, Liu Y, Ha W, Ding LS, Peng SL, Zhang S, Li BJ (2012) Stimuli-induced Gel-sol Transition of Multi-sensitive Supramolecular B-Cyclodextrin Grafted Alginate/Ferrocene Modified Pluronic Hydrogel. Soft Matter 8:5746–5749
Wu WT, Shen J, Gai Z, Hong KL, Banerjee P, Zhou SQ (2011) Multi-Functional Core-Shell Hybrid Nanogels for pH-Dependent Magnetic Manipulation, Fluorescent pH-Sensing, and Drug Delivery. Biomat 32:9876–9887
Wang Y, Dong A, Yuan Z, Chen D (2012) Fabrication and Characterization of Temperature-, pH- and Magnetic-field-sensitive Organic /Inorganic Hybrid Ply (ethylene glycol)-based Hydrogels. Coll Sur A: Physicochem Eng Asp 415:68–76
Kumar M, Vijayakumar G, Tamilarasan R (2019) Synthesis, Characterization and Experimental Studies of Nano Zn–Al–Fe3O4 Blended Alginate/Ca Beads for the Adsorption of Rhodamin B. J Polym Env 27:106–117
Saberi A, Alipour E, Sadeghi M (2019) Superabsorbent magnetic Fe3O4-based starch-poly (acrylic acid) nanocomposite hydrogel for efficient removal of dyes and heavy metal ions from water. J Pol Res 26:271–284
Davaran S, Alimirzalu S, Nejati-Koshki K, Nasrabadi HT, Akbarzadeh A, Khandaghi AA, Abbasian M, Alimohammadi S (2014) Physicochemical characteristics of Fe3O4 magnetic nanocomposites based on Poly(N-isopropylacrylamide) for anti-cancer drug delivery. Asian Pac J Cancer Prev 15:49–54
Papaphilippou PC, Pourgouris A, Marinica O, Taulescu A, Athanasoulos GI, Vekas L, Krasia-Christoforou, (2011) Fabrication and Characterization of Superparamagnetic and Thermoresponsive Hydrogels Based on Oleic-Acid-Coated Fe3O4 Nanoparticles, Hexa ( Ethylene Glycol) Methyl Ether Methacrylate and 2-( Acetoacetoxy) Eethyl Methacrylate. J Magn Mat 323:557–563
Lee ESM, Shuter B, Chan J, Chong MSK, Di ng J, Teoh SH, Beuf O, Briguet A, Tam KC, Choolani M, Wang SC, (2010) The Use of Microgel Iron Oxide Nanoparticles in Studies of Magnetic Resonance Relaxation and Endothelial Progenitor Cell Labeling. Biomat 31:3296–3306
Abasian M, Hooshangi V, Moghadam PN (2017) Synthesis of polyvinyl alcohol hydrogel grafted by modified Fe3O4 nanoparticles: characterization and doxorubicin delivery studies. Iran Polym J 26:313–322
Bhattacharya S, Eckert F, Boyko V, Pich A (2007) Temperature, pH and Magnetic-field-sensitive Hybrid Microgels. Small 3:650–657
Taghvay Nakhjiri M, Bagheri Marandi Gh, Kurdtabar M (2019) Adsorption of Methylene Blue, Brilliant Green and Rhodamine B from Aqueous Solution Using Collagen-g-p(AA-co-NVP)/Fe3O4@SiO2 Nanocomposite Hydrogel. J Polym Env 27:581–599
Abd El-Aziz ME, Youssef AM, Kame S, Turky G (2019) Conducting hydrogel based on chitosan, polypyrrole and magnetite nanoparticles: a broadband dielectric spectroscopy study. Polym Bull 76:3175–3194
Kurdtabar M, Rezanejade Bardajee Gh (2020) Drug release and swelling behavior of magnetic iron oxide nanocomposite hydrogels based on poly (acrylic acid) grafted onto sodium alginate. Polym Bull 77:3001–3015. https://doi.org/10.1007/s00289-019-02894-w
Rezanejade Bardajee Gh, Azimi S, Sharifi BAS, M, (2016) ultrasonically accelerated synthesis of silver nanocomposite hydrogel based on salep biopolymer: application in Rhodamine dye adsorption. Iran Polym J 25:1047–1063
mohammadinezhad A, Bagheri Marandi Gh, Farsadrooh M, Javadian H, (2018) Synthesis of poly (acrylamide-co-itaconic acid)/MWCNTs superabsorbent hydrogel nanocomposite by ultrasound-assisted technique: Swelling behavior and Pb (II) adsorption capacity. Ultrason Sonochem 49:1–12
Zhang X, Lin X, Ding H, He Y, Yang H, Chen Y, Chen X, Luo X (2019) Novel alginate particles decorated with nickel for enhancing ciprofloxacin removal: characterization and mechanism analysis. Ecotoxicol Environ Saf 169:392–401
Ji Y, Chen J, Liu W, Yin D (2019) Construction of highly stretchable silica/polyacrylamide nanocomposite hydrogels through hydrogen bond strategy. J Polym Res 26:119. https://doi.org/10.1007/s10965-019-1761-1
Cai XuG, Jun ShJ, Ji Li D, Long Xing H (2009) On Interaction between nano-Ag and P(AMPS-co-MMA) copolymer synthesized by ultrasonic. J Polym Res 16:295–299. https://doi.org/10.1007/s10965-008-9229-8
Ebrahimi R, Ebrahimi M (2014) the stimuli-response characters of the hydrogels Prepared from Ultrasound. J Polym Eng 34:625–632
Ebrahimi R, Salavaty M (2018) Controlled drug delivery of ciprofloxacin from ultrasonic hydrogel. e-Polym 18:187–195
Ebrahimi R (2019) the study of factors affecting the swelling of ultrasound-prepared hydrogel. Polym Bull 76:1023–1039
Fan T, Li M, Wu X, Wu Y (2011) Preparation of Thermoresponsive and pH-sensitivity Polymer Magnetic Hydrogel Nanospheres as Anticancer Drug Carriers. Colloids Surf, B 88:593–600
Cass P, Knower W, Pereeia E, Holmes Hughes NT (2010) Preparation of Hydrogels via ultrasonic polymerization. Ultrason Sonochem 17:326–332
Kost J, Langer R (2012) Responsive polymeric delivery systems. Adv Drug Deliv Rev 46:327–341
Huynh CT, Nguyen MK, Lee DS (2011) Biodegradable pH/temperature-sensitive oligo (B-amino ester urethane) Hydrogels for Controlled Release of Doxorubicin. Acta Biomat 7:3123–3130
Zarzycki R, Modr Zejewska Z, Nawrotek K (2010) Drug Release from Hydrogel Matrices. Eco Chem Eng 17:117–136
Hajikarimi A, Sadeghi M (2020) Free radical synthesis of cross-linking gelatin base poly NVP/acrylic acid hydrogel and nanoclay hydrogel as cephalexin drug deliver. J Polym Res. https://doi.org/10.1007/s10965-020-2020-1
Tomar RS, Gupta I, Singhal R, Nagpal AK (2007) Synthesis of Poly (Acrylamide-co-Acrylic Acid) based Superabsorbent Hydrogels: Study of Network Parameters and Swelling Behaviour. Polym-Plas Tech Eng 46:481–488
Kodoth AK, Badalamoole V (2020) Silver nanoparticle-embedded pectin-based hydrogel for adsorptive removal of dyes and metal ions. Polym Bull 77:541–564
Yuan Ch, Chen J, Jia Y, Yin D (2020) Preparation of polyglycidyl methacrylate microspheres and nanocomposite hydrogels crosslinked by hydrogen bonds. J Polym Res 27:86. https://doi.org/10.1007/s10965-020-2034-8
Kaur K, Jindal R, Saini D (2020) Synthesis, optimization and characterization of PVA-co-poly (methacrylic acid) green adsorbents and applications in environmental remediation. Polym Bull 77:3079–3100
Gharekhani H, Olad A, Mirmohseni A, Bybordi A (2017) Superabsorbent hydrogel made of NaAlg-g-poly(AA-co-AAm) and rice husk ash: Synthesis, characterization, and swelling kinetic studies. Carbohydrate Polym 168:1–13
Rezanejade Bardji Gh, Khamooshi N, Nasri Sh, Vancaeyzeele C (2020) Multi-stimuli responsive nanogel hydrogel nanocomposites based on κ-carrageenan for prolonged release of levodopa as model drug. Int J Biolog Macromol 153:180–189
Singh J, Dhaliwal AS (2019) Water retention and controlled release of KCl by using microwave-assisted green synthesis of xanthan gum-cl-poly (acrylic acid)/AgNPs hydrogel nanocomposite. Polym Bull. https://doi.org/10.1007/s00289-019-02990-x
Ali MAM, Alsabagh AM, Sabaa MW, El‑Salamony RA, Mohamed RR, Morsi RE Polyacrylamide hybrid nanocomposites hydrogels for efficient water treatment. Iran Polym J. https://doi.org/10.1007/s13726-020-00810-y
Gor AH, Dave PN (2020) Adsorptive abatement of ciprofloxacin using NiFe2O4 nanoparticles incorporated into G. ghatti-cl-P(AAm) nanocomposites hydrogel: isotherm, kinetic, and thermodynamic studies. Polym Bull 77:5589–5613. https://doi.org/10.1007/s00289-019-03032-2
Bai H, Li C, Wang X, Shi G (2010) A pH-sensitive graphene oxide composite hydrogel. Chem Commun 46:2376–2378. https://doi.org/10.1039/c000051e
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare there is no conflicts of interest regarding the publication of this paper. The paper has not been published elsewhere and that it has not been submitted simultaneously for publication elsewhere.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ebrahimi, R., Rezanejade Bardajee, G. Sonochemical synthesis and swelling behavior of Fe3O4 nanocomposite based on poly(acrylamide-co-acrylic acid) hydrogel for drug delivery application. J Polym Res 28, 35 (2021). https://doi.org/10.1007/s10965-020-02382-0
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10965-020-02382-0