The cause of most Parkinson’s disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction and excess α synuclein aggregation, and eventually, Parkinson’s disease.

中文翻译：

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与潜伏病毒的微竞争如何导致 α 突触核蛋白聚集、线粒体功能障碍，并最终导致帕金森病

大多数帕金森病病例的原因尚不清楚。然而，有充分证据表明，线粒体功能障碍和错误折叠的α突触核蛋白聚集是与该疾病相关的重要细胞异常。在本文中，我们使用微竞争模型来展示感染中枢和外周神经系统的潜伏病毒如何导致观察到的线粒体功能障碍和过度的α突触核蛋白聚集，并最终导致帕金森病。