Polymer micelles obtained from amphiphilic copolymers have emerged as promising drug vehicles given their nanometric size, simple release, and encapsulation mechanisms. Nevertheless, their lack of functional groups that interact with the drugs causes low encapsulation capacities. In this paper, the synthesis of an amphiphilic copolymer composed of polyethylene glycol and a poly(ester-co-carbonate) segment containing alkyne groups, as well as its coupling in a post-synthesis stage with other azido-functionalized substances through click reaction, is reported. The modifiers can be intentionally selected to favor polymer–drug compatibility for the rational development of drug delivery systems. Herein, amphotericin B was taken as a model because it is a water-insoluble and highly toxic drug. Cholesterol and oleic acid were employed as modifiers of the copolymers and provided improvements on the drug loading capacity compared with an unmodified copolymer. While oleic acid modified structures presented the highest encapsulation when five units were grafted; a single cholesterol molecule gave the highest enhancement.

从两亲共聚物中获得的聚合物胶束，由于其纳米尺寸，简单的释放和包封机制，已成为有前途的药物载体。然而，它们缺乏与药物相互作用的官能团导致低的包囊能力。在本文中，由聚乙二醇和含有炔基的聚（酯-碳酸酯）链段组成的两亲共聚物的合成，以及在合成后阶段通过点击反应与其他叠氮官能化物质偶联，被报道。可以有选择地选择改性剂，以促进聚合物-药物相容性，从而合理地开发药物输送系统。在此，以两性霉素B为模型，因为它是水不溶性且剧毒的药物。胆固醇和油酸用作共聚物的改性剂，与未改性的共聚物相比，提供了改善的载药量。当接枝五个单元时，油酸修饰的结构表现出最高的包封度；单个胆固醇分子的增强作用最大。