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Investigation in the field of quinazolines. 8*. New reaction of N -alkylation of 4,4-diphenyl-3,4-dihydroquinazolines
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-01-04 , DOI: 10.1007/s10593-020-02848-5
Elena V. Gromachevskava , Elena A. Kaigorogova , Alexander V. Bespalov , Oleg P. Demidov , Gennady D. Krapivin

The reaction of substituted 4,4-diphenyl-3,4(1,4)-dihydroquinazolines with various alkylating agents in DMSO–KOH leads (depending on the structure of the alkylating agent) to the formation of the corresponding N1-monoalkyl-substituted 1,4-dihydroquinazolines or, in the reaction with ethyl bromoacetate, to N-{[5-bromo-2-(methylamino)phenyl]diphenylmethyl}benzamide with opening of the heterocyclic ring. The molecular structures of 1-ethyl-2,4,4-triphenyl-1,4-dihydroquinazoline and 1-ethyl-2-(7-methoxy-1,3-benzodioxol-5-yl)-4,4-diphenyl-1,4-dihydroquinazoline were investigated and proven by X-ray structural analysis.



中文翻译:

喹唑啉领域的研究。8 *。4,4-二苯基-3,4-二氢喹唑啉N-烷基化的新反应

取代的4,4-二苯基-3,4(1,4)-二氢喹唑啉与各种烷基化剂在DMSO-KOH中的反应导致(取决于烷基化剂的结构)形成相应的N 1-单烷基-取代的1,4-二氢喹唑啉或在与溴乙酸乙酯反应中,在杂环开环的情况下生成N -{[5-溴-2-(甲基氨基)苯基]二苯基甲基}苯甲酰胺。1-乙基-2,4,4-三苯基-1,4-二氢喹唑啉和1-乙基-2-(7-甲氧基-1,3-苯并二恶唑-5-基)-4,4-二苯基-的分子结构对1,4-二氢喹唑啉进行了研究,并通过X射线结构分析对其进行了验证。

更新日期:2021-01-04
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