Journal of Fluorescence ( IF 2.6 ) Pub Date : 2021-01-02 , DOI: 10.1007/s10895-020-02659-z Hytham Hassan 1 , Rama Alqassar Bani Almarjeh 1 , Yomen Atassi 1
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In this study, nitrogen-doped carbon quantum dots CQDs, synthesized from malic acid and EDTA, were encapsulated using sodium alginate. Different parameters affecting loading capacity (such as capsules’ sizes, complexation solution’s concentration and encapsulation method) were investigated. After that, ibuprofen (Ibu), taken as a model drug, was tagged by CQDs to form Ibu-CQDs adduct, and then encapsulated using sodium alginate. The results showed high values of loading capacity of CQDs, ibu and Ibu-CQDs capsules; 86.3%, 92% and 67%, respectively. It was proved that Ibu-CQDs release could be tracked using spectrofluorometry and UV-vis spectroscopy. The maximum release of Ibu-CQDs was 42% after 24 h. Temperature’s effect on drug release was also studied and it was found that the best release was achieved at higher temperatures (40 °C), which corresponds to the illness state. Release medium’s pH was also varied to simulate the pH of different parts of the gastrointestinal tract, and it was found that the best drug release can occur in the duodenum instead of the stomach. The current Ibu-CQDs capsules hold great promise for further studies in drug release and bioimaging applications.
Graphical abstract
中文翻译：
使用碳量子点进行体外布洛芬释放监测
在这项研究中，由苹果酸和 EDTA 合成的氮掺杂碳量子点 CQD 使用海藻酸钠进行封装。研究了影响负载能力的不同参数（例如胶囊的尺寸、络合溶液的浓度和封装方法）。之后，以布洛芬（Ibu）作为模型药物，通过CQDs标记形成Ibu-CQDs加合物，然后用海藻酸钠进行胶囊化。结果显示 CQDs、ibu 和 Ibu-CQDs 胶囊具有较高的负载能力；分别为 86.3%、92% 和 67%。事实证明，可以使用荧光分光光度法和紫外可见光谱来跟踪 Ibu-CQD 的释放。 24 小时后 Ibu-CQD 的最大释放量为 42%。还研究了温度对药物释放的影响，发现在较高温度（40°C）下实现最佳释放，这与疾病状态相对应。释放介质的pH值也被改变以模拟胃肠道不同部位的pH值，并且发现最佳的药物释放可以发生在十二指肠而不是胃中。目前的 Ibu-CQD 胶囊对于药物释放和生物成像应用的进一步研究具有广阔的前景。
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