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In-Vitro Ibuprofen Release Monitoring Using Carbon Quantum Dots

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Abstract

In this study, nitrogen-doped carbon quantum dots CQDs, synthesized from malic acid and EDTA, were encapsulated using sodium alginate. Different parameters affecting loading capacity (such as capsules’ sizes, complexation solution’s concentration and encapsulation method) were investigated. After that, ibuprofen (Ibu), taken as a model drug, was tagged by CQDs to form Ibu-CQDs adduct, and then encapsulated using sodium alginate. The results showed high values of loading capacity of CQDs, ibu and Ibu-CQDs capsules; 86.3%, 92% and 67%, respectively. It was proved that Ibu-CQDs release could be tracked using spectrofluorometry and UV-vis spectroscopy. The maximum release of Ibu-CQDs was 42% after 24 h. Temperature’s effect on drug release was also studied and it was found that the best release was achieved at higher temperatures (40 °C), which corresponds to the illness state. Release medium’s pH was also varied to simulate the pH of different parts of the gastrointestinal tract, and it was found that the best drug release can occur in the duodenum instead of the stomach. The current Ibu-CQDs capsules hold great promise for further studies in drug release and bioimaging applications.

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The authors declare that the current manuscript have only “Supplementary Information’s Document” as data and materials.

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Not applicable. The current work is an academic work in a higher education institute.

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Authors and Affiliations

  1. Materials Sciences Laboratory, Higher Institute for Applied Sciences and Technology, Damascus, Syria

    Hytham Hassan, Rama Alqassar Bani Almarjeh & Yomen Atassi

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  1. Hytham Hassan
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  2. Rama Alqassar Bani Almarjeh
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  3. Yomen Atassi
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Contributions

Hytham Hassan: Collected the data, performed the analysis, and participate in writing the paper.

Rama Alqassar Bani Almarjeh: Conceived and designed the analysis, performed the analysis, and participate in writing the paper.

Yomen Atassi: Supervised the whole work, Conceived and designed the analysis, performed the analysis, participate in writing the paper and revised the whole work.

Corresponding author

Correspondence to Yomen Atassi.

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Hassan, H., Almarjeh, R.A.B. & Atassi, Y. In-Vitro Ibuprofen Release Monitoring Using Carbon Quantum Dots. J Fluoresc 31, 289–303 (2021). https://doi.org/10.1007/s10895-020-02659-z

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  • DOI: https://doi.org/10.1007/s10895-020-02659-z

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