Abstract

The manuscript represents synthesis of pH and salt responsive hydrogel based on guar gum as a renewable substrate for drug delivery of natural anticancer drug i.e. curcumin. Initially acrylic acid grafted guar gum (GG-g-PAA) hydrogel was obtained in the presence of ammonium persulphate as a redox initiator. Structural stability of grafted copolymer was improved using N, N-methylenebisacrylamide as a crosslinker with simultaneous loading of curcumin as a natural anticancer drug. Delivery rate of curcumin from GG-g-PAA was studied by UV spectrophotometer. The neat and drug loaded hydrogels were characterized using FTIR, NMR, TGA, and SEM techniques for their structural, morphological, and thermal behaviours. Swelling of the hydrogels and water diffusion properties were studied in salt and aqueous solutions of different pH. Finally, the fabricated hydrogel matrices were tested for curcumin release studies to understand the release kinetic. The results indicated that the prepared renewable source based hydrogel can be used in drug delivery of curcumin as a natural medicine. As curcumin and guar gum are products of agricultural food crops viz. turmeric and guar, the current research can be a good contribution towards preparation of an eco-friendly drug delivery system based on agriculture products.

Graphic Abstract

中文翻译：

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基于瓜尔豆胶的姜黄素可再生材料的pH和盐响应水凝胶：一种天然抗癌药物

摘要

该手稿代表了基于瓜尔豆胶的pH和盐响应性水凝胶的合成，瓜尔胶作为天然抗癌药物即姜黄素的药物递送的可再生基质。最初在过硫酸铵作为氧化还原引发剂的情况下获得了丙烯酸接枝的瓜尔胶（GG-g-PAA）水凝胶。使用N，N-亚甲基双丙烯酰胺作为交联剂，同时加入姜黄素作为天然抗癌药物，可以改善接枝共聚物的结构稳定性。用紫外分光光度计研究了姜黄素从GG-g-PAA的传递速率。使用FTIR，NMR，TGA和SEM技术对纯净和载有药物的水凝胶的结构，形态和热行为进行了表征。在不同pH的盐和水溶液中研究了水凝胶的溶胀和水扩散特性。最后，对制备的水凝胶基质进行姜黄素释放研究，以了解其释放动力学。结果表明，所制备的基于可再生资源的水凝胶可以作为天然药物用于姜黄素的药物递送。由于姜黄素和瓜尔豆胶是农作物的产品即。姜黄和瓜耳胶，目前的研究可以为基于农产品的生态友好型药物输送系统的制备做出很好的贡献。

图形摘要