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pH and Salt Responsive Hydrogel based on Guar Gum as a Renewable Material for Delivery of Curcumin: A Natural Anti-Cancer Drug

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Abstract

The manuscript represents synthesis of pH and salt responsive hydrogel based on guar gum as a renewable substrate for drug delivery of natural anticancer drug i.e. curcumin. Initially acrylic acid grafted guar gum (GG-g-PAA) hydrogel was obtained in the presence of ammonium persulphate as a redox initiator. Structural stability of grafted copolymer was improved using N, N-methylenebisacrylamide as a crosslinker with simultaneous loading of curcumin as a natural anticancer drug. Delivery rate of curcumin from GG-g-PAA was studied by UV spectrophotometer. The neat and drug loaded hydrogels were characterized using FTIR, NMR, TGA, and SEM techniques for their structural, morphological, and thermal behaviours. Swelling of the hydrogels and water diffusion properties were studied in salt and aqueous solutions of different pH. Finally, the fabricated hydrogel matrices were tested for curcumin release studies to understand the release kinetic. The results indicated that the prepared renewable source based hydrogel can be used in drug delivery of curcumin as a natural medicine. As curcumin and guar gum are products of agricultural food crops viz. turmeric and guar, the current research can be a good contribution towards preparation of an eco-friendly drug delivery system based on agriculture products.

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Acknowledgements

This project has received funding from the Deanship of Scientific Research, King Faisal University, Al-Ahsa, Saudi Arabia. Grant Number-1811009.

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Authors and Affiliations

  1. Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

    Afzal HaqAsif

  2. School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, 425001, MS, India

    Rahul R. Karnakar, Vikas V. Gite & Niteen Borane

  3. Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

    Nagaraja Sreeharsha & Bandar E. Al-Dhubiab

  4. Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, 560 035, India

    Nagaraja Sreeharsha

  5. Department of Dermatology, College of Medicine, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

    Feroze Kaliyadan

  6. Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

    Tasleem Rasool

  7. Department of Pharmaceutics, KLE College of Pharmacy, Bangalore, 560 010, India

    Shivakumar H. Nanjappa

  8. Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, 31982, Saudi Arabia

    Girish Meravanige

Authors
  1. Afzal HaqAsif
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  2. Rahul R. Karnakar
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  3. Nagaraja Sreeharsha
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  4. Vikas V. Gite
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  6. Bandar E. Al-Dhubiab
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  9. Shivakumar H. Nanjappa
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  10. Girish Meravanige
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All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

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Correspondence to Nagaraja Sreeharsha.

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HaqAsif, A., Karnakar, R.R., Sreeharsha, N. et al. pH and Salt Responsive Hydrogel based on Guar Gum as a Renewable Material for Delivery of Curcumin: A Natural Anti-Cancer Drug. J Polym Environ 29, 1978–1989 (2021). https://doi.org/10.1007/s10924-020-01934-1

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  • DOI: https://doi.org/10.1007/s10924-020-01934-1

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