The fabrication of silver nanoclusters with good cellular uptaking behaviors and the property of easy separation and redispersion without aggregation is a thorny problem. In this work, the nanosilica supported silver nanoclusters were prepared by method of situ photochemical reduction of silver precursor on the carboxylated silica nanoparticles. The composite silver nanoclusters showed excellent fluorescent emission properties, good photostability and can be separated from aqueous phase by centrifugation, then can be redispersed in the water environment without affecting its fluorescence emission properties. Further, the vitro cancer cell imaging experiments showed that the composite silver clusters have good cellular uptaking behaviors and excellent biocompatibility. Thus, the composite silver cluster showed good potential application prospects in the field of biomarkers.

具有良好的细胞吸收行为以及易于分离和再分散而不聚集的性质的银纳米簇的制备是一个棘手的问题。在这项工作中，通过原位光化学还原羧化二氧化硅纳米粒子上的银前驱体的方法，制备了纳米二氧化硅负载的银纳米团簇。该复合银纳米团簇具有优异的荧光发射性能，良好的光稳定性，可以通过离心与水相分离，然后可以在水环境中重新分散而不影响其荧光发射性能。此外，体外癌细胞成像实验表明，复合银簇具有良好的细胞摄取行为和优异的生物相容性。从而，