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Biocompatible, Easily Separated and Dispersed Silver Clusters for Imaging of Cancer Cells

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Abstract

The fabrication of silver nanoclusters with good cellular uptaking behaviors and the property of easy separation and redispersion without aggregation is a thorny problem. In this work, the nanosilica supported silver nanoclusters were prepared by method of situ photochemical reduction of silver precursor on the carboxylated silica nanoparticles. The composite silver nanoclusters showed excellent fluorescent emission properties, good photostability and can be separated from aqueous phase by centrifugation, then can be redispersed in the water environment without affecting its fluorescence emission properties. Further, the vitro cancer cell imaging experiments showed that the composite silver clusters have good cellular uptaking behaviors and excellent biocompatibility. Thus, the composite silver cluster showed good potential application prospects in the field of biomarkers.

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Acknowledgements

The financial support of this research was from Tianjin Municipal Education Commission (2017KJ027).

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Authors and Affiliations

  1. Department of Chemistry, School of Science, Tianjin University of Science & Technology, Tianjin, 300457, China

    Xumei Wang, Dehua Cheng, Qingxue Ma, Qing Yi, Yanling Guo & Hongxiang Xie

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  1. Xumei Wang
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  2. Dehua Cheng
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  3. Qingxue Ma
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  4. Qing Yi
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  5. Yanling Guo
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  6. Hongxiang Xie
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Correspondence to Xumei Wang or Hongxiang Xie.

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Wang, X., Cheng, D., Ma, Q. et al. Biocompatible, Easily Separated and Dispersed Silver Clusters for Imaging of Cancer Cells. J Clust Sci 33, 189–195 (2022). https://doi.org/10.1007/s10876-020-01922-4

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  • DOI: https://doi.org/10.1007/s10876-020-01922-4

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