Background and Objective

Dissecting cellulitis of the scalp is a primary scarring alopecia. Isotretinoin is commonly referenced in the literature as a treatment for dissecting cellulitis. The objective of this article was to conduct a review and meta-analysis to assess the efficacy of isotretinoin for treating dissecting cellulitis of the scalp.

Methods

The following databases were searched for articles prior to 23 June, 2019: PubMed, Embase, Cochrane Central, CINAHL, and Web of Science. Multi-patient studies (more than three) that reported on the administration of isotretinoin for dissecting cellulitis were included. A pooled meta-analysis for improvement of disease burden after isotretinoin administration in patients with dissecting cellulitis of the scalp was performed. A fixed-effects model was used.

Results

Five articles were ultimately used for the quantitative meta-analysis. The overall efficacy rate of isotretinoin in treating dissecting cellulitis of the scalp was estimated to be 0.9 with a 95% confidence interval (0.81–0.97). The sensitivity analysis suggested that the overall efficacy is still very high, with a range of 0.83–0.94. Recurrence was seen in 24% (6/25) of patients. Common associated diseases amongst patients with dissecting cellulitis of the scalp were acne conglobata 20% (30/151) and hidradenitis suppurativa 19% (11/72).

Conclusions

Isotretinoin is an effective treatment for improving symptoms of dissecting cellulitis of the scalp. Disease recurrence is a common finding for those who undergo successful treatment.

中文翻译：

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异维A酸治疗夹层性蜂窝组织炎的疗效分析：文献综述与荟萃分析

背景与目的

解剖头皮蜂窝组织炎是一种主要的瘢痕性脱发。异维A酸在文献中通常被称为解剖蜂窝组织炎的治疗方法。本文的目的是进行审查和荟萃分析，以评估异维A酸在治疗头皮解剖性蜂窝织炎中的功效。

方法

在以下数据库中搜索了2019年6月23日之前的文章：PubMed，Embase，Cochrane Central，CINAHL和Web of Science。纳入了多名患者的研究（三项以上），这些研究报告了异维A酸用于解剖蜂窝组织炎的方法。进行荟萃分析，以改善异位维甲酸治疗头皮夹层蜂窝织炎患者的疾病负担。使用了固定效果模型。

结果

最终有五篇文章用于定量荟萃分析。异维A酸治疗头皮解剖性蜂窝组织炎的总有效率估计为0.9，置信区间为95％（0.81-0.97）。敏感性分析表明，总体疗效仍然很高，范围为0.83–0.94。24％（6/25）的患者可见复发。头皮夹层蜂窝织炎患者中常见的相关疾病是痤疮痤疮20％（30/151）和化脓性汗腺炎19％（11/72）。

结论

异维A酸是改善夹层头皮蜂窝组织炎症状的有效方法。对于那些成功接受治疗的人来说，疾病复发是一个普遍的发现。