This study represents a simple and facile method for the fabrication of gold nanoparticles (AuNPs) using Cephradine (Cep) drug as a capping agent. Synthesized Cep-AuNPs have been characterized using different modern analytical techniques such as UV–Vis spectroscopy, X-ray diffractometry, and Atomic Force Microscopy. The estimated average size of synthesized gold nanoparticles was found up to 30 nm. These Cep-AuNPs has been used for the highly selective and sensitive colorimetric sensing for the mitoxantrone (MX) detection. The linear range of proposed colorimetric sensor responded to MX in the range of 10–100 µg/L. The detection and quantification limit of the sensor was 3.5 µg/L and 11.9 µg/L, respectively. The developed sensor was highly selected and highly efficient for MX detection as compared with other coexisting compounds such as 5Florourical, Capecitabine, Methotrexate (MTX), Zoledronic Acid. This developed sensor was successfully applied for the detection of MX from the real biological samples. The developed colorimetric sensor is sensitive, selective, cheaper and no need for sample preparation and easy to operate. No need expansive instruments.

这项研究代表了一种使用头孢拉定（Cep）药物作为封端剂的金纳米颗粒（AuNPs）的简便生产方法。合成的Cep-AuNPs已使用不同的现代分析技术进行了表征，例如UV-Vis光谱，X射线衍射法和原子力显微镜。发现合成金纳米颗粒的估计平均尺寸高达30nm。这些Cep-AuNP已用于米托蒽醌（MX）检测的高度选择性和灵敏的比色传感。建议的比色传感器的线性范围在10–100 µg / L的范围内对MX响应。传感器的检测限和定量限分别为3.5 µg / L和11.9 µg / L。与5Florourical，卡培他滨，甲氨蝶呤（MTX），唑来膦酸等其他共存化合物相比，开发的传感器在MX检测方面具有很高的选择和效率。这种开发的传感器已成功应用于从真实生物样品中检测MX。研发的比色传感器灵敏，选择性强，价格便宜，无需样品制备且易于操作。无需扩展工具。