Despite many years of intensive investigation, real biological role of SERPINB2 is largely unknown. However, recent high throughput studies suggest its function in inflammation, influence on autoimmune disorders, and modulation of processes leading to carcinogenesis. SERPINB2 expression is acutely upregulated by many different stimuli, among others by aryl hydrocarbon receptor ligands. Mechanisms of regulation of SERPINB2 expression, involvement of the gene in processes leading to inflammation or carcinogenesis, and its interplay with aryl hydrocarbon receptor are subject of present review.

中文翻译：

---

SERPINB2——它的调节和与芳烃受体的相互作用

尽管经过多年的深入研究，SERPINB2 的真正生物学作用在很大程度上是未知的。然而，最近的高通量研究表明其在炎症中的功能、对自身免疫性疾病的影响以及导致致癌过程的调节。SERPINB2表达被许多不同的刺激急剧上调，其中包括芳烃受体配体。SERPINB2表达的调节机制、该基因参与导致炎症或致癌的过程，以及它与芳烃受体的相互作用是本综述的主题。