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SERPINB2—its regulation and interplay with aryl hydrocarbon receptor

  • Human Genetics • Review
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Abstract

Despite many years of intensive investigation, real biological role of SERPINB2 is largely unknown. However, recent high throughput studies suggest its function in inflammation, influence on autoimmune disorders, and modulation of processes leading to carcinogenesis. SERPINB2 expression is acutely upregulated by many different stimuli, among others by aryl hydrocarbon receptor ligands. Mechanisms of regulation of SERPINB2 expression, involvement of the gene in processes leading to inflammation or carcinogenesis, and its interplay with aryl hydrocarbon receptor are subject of present review.

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Abbreviations

P-TEFb:

positive transcription elongation factor

CDK9:

cyclin-dependent kinase 9 associated with P-TEFb

NELF:

negative elongation factor

eRNA:

enhancer RNA

TPA:

12-O-tetradecanoylphorbol-13-acetate

AP-1:

activator protein 1

CRE :

cAMP-responsive element

BNF:

β-naphthoflavone

BaP:

benzo[a]pyrene

TCDD:

2,3,7,8-tetrachlorodibenzo-p-dioxin

LPS:

bacterial lipopolysaccharide

SERPINB2:

serpin peptidase inhibitor B2

AhR:

aryl hydrocarbon receptor

CYP1A1:

cytochrome P450 1A1

PXK:

PX domain containing serine/threonine kinase

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Funding

This study was funded by statutory funding (Institute of Human Genetics, PAS).

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  1. Institute of Human Genetics, Polish Academy of Sciences, ul. Strzeszyńska 32, 60-479, Poznań, Poland

    Damian Brauze

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  1. Damian Brauze
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Correspondence to Damian Brauze.

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Communicated by: Michal Witt

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Brauze, D. SERPINB2—its regulation and interplay with aryl hydrocarbon receptor. J Appl Genetics 62, 99–105 (2021). https://doi.org/10.1007/s13353-020-00606-z

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